Publications by authors named "Kapil Thapa"
At the time of breast cancer diagnosis, most patients meet the diagnostic criteria to be classified as obese or overweight. This can significantly impact patient outcome: breast cancer patients with obesity (body mass index > 30) have a poorer prognosis compared to patients with a lean BMI. Obesity is associated with hyperleptinemia, and leptin is a well-established driver of metastasis in breast cancer.
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- The study focuses on how autophagy impacts the hepatic proteome, especially regarding the degradation and regulation of liver proteins.
- Researchers found that when autophagy is impaired, certain proteins like Cps1, Ahcy, and Ca3 decrease, while Gstm1 increases due to changes in mRNA levels rather than just degradation.
- The results highlight that autophagy affects liver proteins not only through degradation but also by influencing gene expression via the Nrf2 transcription factor.
Effect of the COVID-19 Lockdown on Ambient Air Quality in Major Cities of Nepal.
J Health Pollut
March 2021
Background: The Nepalese government announced a nationwide lockdown beginning on March 24, 2020 as an attempt to restrain the spread of COVID-19. The prohibition in flight operations and movement of vehicles, factory shutdowns and restriction in people's movement due to the lockdown led to a significant reduction in the amounts of pollutants degrading air quality in many countries.
Objectives: The present study aimed to analyze changes in particulate matter (PM) emissions and the air quality index (AQI) of six cities in Nepal i.