Novel bicephalous heterolipid based self-microemulsifying drug delivery system for solubility and bioavailability enhancement of efavirenz.

There is an increasing demand for new lipidic biocompatible and safe materials for self-microemulsifying drug delivery system (SMEDDS). The present work reports the synthesis, characterization, oral mucosal irritation study, and application of novel erucic acid ester of G-PETIM dendron based bicephalous heterolipid (BHL) as an oil phase in SMEDDS using Efavirenz (EFA), a BCS class II drug with poor water solubility and poor bioavailability. Studies were conducted to optimize EFA SMEDDS using different ratios of the BHL as oil phase and surfactant: co-surfactant weight ratios (Km).

Fatty Acid Esters of G-(Propyl Ether Imine) Dendron as Bicephalous Heterolipids for Permeation Enhancement in Transdermal Drug Delivery.

The objective of the present study was to synthesize, evaluate, and explore the potential of a new class of bicephalous heterolipids (BHLs) as chemical permeation enhancers (CPEs) with emphasis on investigation of the influence of variable chain lengths of BHLs with the G-PETIM (poly(propyl ether imine)) dendron as a headgroup on skin permeation efficiency using diclofenac sodium (DS) as a model drug. These BHLs were synthesized, and chemical structures were confirmed by FT-IR, H NMR, C NMR, and ESI-MS. All BHLs were assessed for cytotoxicity and skin irritation studies that revealed their dermal safety.

Xyloglucan: A functional biomacromolecule for drug delivery applications.

The near future of drug delivery system would lie in the search of a versatile and innocuous material, based mostly on the natural resources. The tamarind seed xyloglucan (XG) is a natural neutral hemicellulose and a hydrophilic polysaccharide consisting of a main chain of glucan backbone with xylose and galactose side chains. XG is endowed with idiosyncratic mucoadhesive and in situ gelling properties which rated XG as an attractive, functional polymer for numerous drug delivery applications.