Publications by authors named "Kaoutar Allou"
Gravitational stress occurs during space flights or certain physical activities including extreme sports, where the change in experienced gravitational acceleration can reach large magnitudes. These changes include reduction and increase in the physical forces experienced by the body and may potentially induce pathogenic alterations of physiological processes. The immune system is known to regulate most functions in the human organism and previous studies suggest an impairment of the immune function under gravitational stress.
View Article and Find Full Text PDFBackground: In this study, we primarily sought to assess the ability of flow cytometry to predict early clinical deterioration and overall survival in patients with sepsis admitted in the ED and ICU.
Methods: Patients admitted for community-acquired acute sepsis from 11 hospital centers were eligible. Early (day 7) and late (day 28) deaths were notified.
Article Synopsis
- The study examines the use of minimal residual disease (MRD) assessment in acute myeloblastic leukemia as a prognostic tool, utilizing multiparameter flow cytometry (MFC) to track leukemia-specific immunophenotypes for better patient outcomes.
- Conducted across 10 different MFC centers with 276 patients, it established a standardized method for analyzing MRD using specific immunophenotypic markers, leading to consistent results in monitoring disease status.
- Findings reveal that negative MRD levels significantly correlate with better survival rates, while any positive MRD levels indicate poorer outcomes, regardless of cytogenetic risk factors, thus proving MRD's critical role in patient stratification.
The HematoFlow™ system is used in the hematology laboratory of the University Hospital of Bordeaux since July, 2011. The HematoFlow™ solution is the combination of a sample preparator (FP1000) and a 5 color flow cytometer (FC500) linked by a middleware (Remisol™). This system is used in second line when flags are activated by the hematology instrument and/or if the sample comes from the OncoHematology Department.
View Article and Find Full Text PDFIn spite of intensive research to improve treatment of acute myeloid leukemia (AML) more than half of all patients continue to develop a refractory disease. Therefore there is need to improve AML treatment. The overexpression of the BCL-2 family anti-apoptotic members, like BCL-2 or BCL-xL has been largely reported in lymphoid tumors but also in AML and other tumors.
View Article and Find Full Text PDFThe complete blood cell count and white blood cell differential are the first step in the biological diagnosis of hematological diseases. Both are currently performed by automated instruments which control data and produce alerts. If such flags are activated, the automated differential cannot be validated and the operator must activate a visual blood smear review.
View Article and Find Full Text PDFBackground: Refractory anemia with ring sideroblasts associated with marked thrombocytosis was proposed as a provisional entity in the 2001 World Health Organization classification of myeloid neoplasms and also in the 2008 version, but its existence as a single entity is contested. We wish to define the clinical features of this rare myelodysplastic/myeloproliferative neoplasm and to compare its clinical outcome with that of refractory anemia with ring sideroblasts and essential thrombocythemia.
Design And Methods: We conducted a collaborative retrospective study across Europe.