Loss of ectonucleotidases from the coronary vascular bed after ischemia-reperfusion in isolated rat heart.

Background: Ectonucleotidase plays an important role in the regulation of cardiac function by controlling extracellular levels of adenine nucleotides and adenosine. To determine the influence of ischemia-reperfusion injury on ectonucleotidase activity in coronary vascular bed, we compared the metabolic profile of adenine nucleotides during the coronary circulation in pre- and post-ischemic heart.

Methods: Langendorff-perfused rat hearts were used to assess the intracoronary metabolism of adenine nucleotides.

Local application of nucleus pulposus induces expression OF P2X3 in rat dorsal root ganglion cells.

The P2X(3) receptor is a ligand-gated cation channel that is activated by extra cellular adenosine triphosphate (ATP) found in the dorsal root, trigeminal and nodose ganglia. It is one of the receptors transmitting nociceptive information of injuries and inflammation of the periphery by endogenous ATP released from damaged cells. The present study was performed in order to evaluate if there was an increased expression of P2X(3)-immunoreactivity in dorsal root ganglion (DRG) neurons after experimental disc herniation.

Two cases of idiopathic superior laryngeal neuralgia treated by superior laryngeal nerve block with a high concentration of lidocaine.

Carbamazepine therapy is among the most effective drug regimens to treat patients who have superior laryngeal neuralgia similar to trigeminal neuralgia. However, some patients are resistant to carbamazepine. We report two patients with superior laryngeal neuralgia who were successfully treated with superior laryngeal block using high concentrations of lidocaine, after treatment with carbamazepine failed.