Publications by authors named "Kaoru Shiono"
To examine the effects of telmisartan on peroxisome proliferator-activated receptor gamma activation, we compared the effects of telmisartan with those of candesartan on adipocytokines and glucose and lipid metabolism in vivo and in vitro. In vivo, 56 patients with both type 2 diabetes and hypertension were enrolled and randomized to receive either telmisartan (40 mg) or candesartan (8 mg) for 3 months. Serum adiponectin, HbA1c levels, lipid profiles and blood pressure were recorded at the beginning and 3 months later.
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- The study aimed to assess the effects of switching from premixed human insulin to a rapid-acting insulin analogue in type 2 diabetes patients.
- Researchers enrolled 30 patients and randomized them into two groups: one continued with human insulin, while the other switched to a premixed insulin analogue for four months, with adjustments made to their doses.
- Results showed significant improvement in HbA1c levels for the insulin analogue group, while quality of life remained unchanged, suggesting it may be a better option for managing blood sugar in these patients.