Circular walking is useful for assessing the risk of falls in early progressive supranuclear palsy.

Background: Progressive supranuclear palsy (PSP) is characterized by early onset postural instability and frequent falls. Circular walking necessitates dynamic postural control, which is impaired in patients with PSP. We aimed to explore gait parameters associated with the risk of falls in patients with PSP, focusing on circular walking.

Is there a spinal tap responder in progressive supranuclear palsy? The first prospective study.

Objective: Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disease, and sometimes shows idiopathic normal pressure hydrocephalus (iNPH)-like presentations. We aimed to evaluate spinal tap responsiveness in patients with PSP, including the effect of sham spinal tap.

Methods: Eleven patients with PSP, ten with probable/definite iNPH, and eight control patients were prospectively enrolled.

Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson's disease patients.

Background: The sequence effect (SE) is characterized by the progressive decrement of movements and is often observed in Parkinson's disease (PD) patients. While acute effect of levodopa does not ameliorate the SE, the effect of long-term levodopa treatment for the SE remains unknown.

Objective: We aimed to elucidate the SEs during various gait conditions and their response to long-term levodopa treatment in drug-naïve PD patients.