Redox-based ion-gating reservoir consisting of (104) oriented LiCoO film, assisted by physical masking.

Reservoir computing (RC) is a machine learning framework suitable for processing time series data, and is a computationally inexpensive and fast learning model. A physical reservoir is a hardware implementation of RC using a physical system, which is expected to become the social infrastructure of a data society that needs to process vast amounts of information. Ion-gating reservoirs (IGR) are compact and suitable for integration with various physical reservoirs, but the prediction accuracy and operating speed of redox-IGRs using WO as the channel are not sufficient due to irreversible Li trapping in the WO matrix during operation.

A Novel Plant-Derived Choline Transporter-like Protein 1 Inhibitor, Amb544925, Induces Apoptotic Cell Death via the Ceramide/Survivin Pathway in Tongue Squamous Cell Carcinoma.

Background: Despite recent advances in the early detection and treatment of TSCC patients, recurrence rates and survival rates have not improved. The high frequency of lymph node metastasis is one of the causes, and the drug development of new therapeutic mechanisms such as metastasis control is desired. Choline transporter-like protein 1 (CTL1) has attracted attention as a target molecule in cancer therapy.

Nanoscale Relaxation in "Water-in-Salt" and "Water-in-Bisalt" Electrolytes.

"Water-in-salt" (WIS) and "water-in-bisalt" (WIBS) electrolytes have recently been developed for Li-ion batteries, combining the safety and environmental friendliness of aqueous electrolytes with a larger operating window made possible by a solid-electrolyte interphase. We report quasielastic neutron scattering (QENS) measurements on solutions of a WIS electrolyte at two concentrations, 13.9 and 21 (molal) lithium bis(trifluoromethane)sulfonimide LiTFSI in HO/DO and a WIBS electrolyte at (21 LiTFSI + 7 lithium triflate (LiOTf)) in HO/DO.

Molecular and Functional Analysis of Choline Transporters and Antitumor Effects of Choline Transporter-Like Protein 1 Inhibitors in Human Pancreatic Cancer Cells.

Choline, an organic cation, is one of the biofactors that play an important role in the structure and the function of biological membranes, and it is essential for the synthesis of phospholipids. Choline positron emission tomography-computed tomography (PET/CT) provides useful information for the imaging diagnosis of cancers, and increased choline accumulation has been identified in a variety of tumors. However, the molecular mechanisms of choline uptake and choline transporters in pancreatic cancer have not been elucidated.

Anticancer Activity of Amb4269951, a Choline Transporter-Like Protein 1 Inhibitor, in Human Glioma Cells.

Choline transporter-like protein 1 (CTL1) is highly expressed in glioma cells, and inhibition of CTL1 function induces apoptotic cell death. Therefore, CTL1 is a potential target molecule for glioma therapy. Here, we investigated the therapeutic mechanism underlying the antitumor effects of Amb4269951, a recently discovered novel CTL1 inhibitor, in the human glioma cell line U251MG, and evaluated its in vivo effects in a mouse xenograft model.

Segmental Motions of Proteins under Non-native States Evaluated Using Quasielastic Neutron Scattering.

Characterization of the dynamics of disordered polypeptide chains is required to elucidate the behavior of intrinsically disordered proteins and proteins under non-native states related to the folding process. Here we develop a method using quasielastic neutron scattering, combined with small-angle X-ray scattering and dynamic light scattering, to evaluate segmental motions of proteins as well as diffusion of the entire molecules and local side-chain motions. We apply this method to RNase A under the unfolded and molten-globule (MG) states.

Dynamic Properties of Human α-Synuclein Related to Propensity to Amyloid Fibril Formation.

α-Synuclein (αSyn) is an intrinsically disordered protein that can form amyloid fibrils. Fibrils of αSyn are implicated with the pathogenesis of Parkinson's disease and other synucleinopathies. Elucidating the mechanism of fibril formation of αSyn is therefore important for understanding the mechanism of the pathogenesis of these diseases.

Quasielastic neutron scattering of brucite to analyse hydrogen transport on the atomic scale.

It is demonstrated that quasielastic neutron scattering is a novel and effective method to analyse atomic scale hydrogen transport processes occurring within a mineral crystal lattice. The method was previously characterized as sensitive for analysing the transport frequency and distance of highly diffusive hydrogen atoms or water molecules in condensed matter. Here are shown the results of its application to analyse the transport of much slower hydrogen atoms which are bonded into a crystal lattice as hydroxyls.

Neutron scattering studies on short- and long-range layer structures and related dynamics in imidazolium-based ionic liquids.

Alkyl-methyl-imidazolium ionic liquids CnmimX (n: alkyl-carbon number, X: anion) have short-range layer structures consisting of ionic and neutral (alkylchain) domains. To investigate the temperature dependences of the interlayer, interionic group, and inter-alkylchain correlations, we have measured the neutron diffraction (ND) of C16mimPF, C9.5mimPF, and C8mimPF in the temperature region from 4 K to 470 K.

Simple Technique for Reducing the Buccal Fat Pad During Mandibular Orthognathic Surgery.

Sagittal split ramus osteotomy and intraoral vertical ramus osteotomy are commonly performed for the correction of jaw deformities. However, during mandibular orthognathic surgeries such as sagittal split ramus osteotomy and intraoral vertical ramus osteotomy , the authors sometimes encounter exposure of the buccal fat pad (BFP), which decreases the surgical field. The exposed BFP makes it difficult to perform these operations, may result in unexpected complications, and may increase the operation time.

Experimental investigation of the glass transition of polystyrene thin films in a broad frequency range.

In this study, we investigate the α process of a polystyrene thin film using inelastic neutron scattering (INS), dielectric relaxation spectroscopy (DRS), and thermal expansion spectroscopy (TES). The DRS and TES measurements exhibited a decrease in glass transition temperature (T_{g}) with film thickness. On the other hand, an increase in T_{g} was observed in INS studies.

Quasielastic neutron scattering study of microscopic dynamics in polybutadiene reinforced with an unsaturated carboxylate.

We studied the dynamics of zinc diacrylate (ZDA) reinforced polybutadiene rubber (BR) (ZDA/BR) using the quasielastic neutron scattering technique to determine the effect of concentration of ZDA on polymer dynamics. First, we evaluated the temperature dependence of mean square displacements (〈u〉) for ZDA/BR with different ZDA volume fractions. 〈u〉 increased with temperature below 170 K, and we observed no significant ZDA volume fraction dependence.

Modulation of the picosecond dynamics of troponin by the cardiomyopathy-causing mutation K247R of troponin T observed by quasielastic neutron scattering.

Troponin (Tn), consisting of three subunits (TnC, TnI, and TnT), regulates cardiac muscle contraction in a Ca-dependent manner. Various point mutations of human cardiac Tn are known to cause familial hypertrophic cardiomyopathy due to aberration of the regulatory function. In this study, we investigated the effects of one of these mutations, K247R of TnT, on the picosecond dynamics of the Tn core domain (Tn-CD), consisting of TnC, TnI and TnT2 (183-288 residues of TnT), by carrying out the quasielastic neutron scattering measurements on the reconstituted Tn-CD containing either the wild-type TnT2 (wtTn-CD) or the mutant TnT2 (K247R-Tn-CD) in the absence and presence of Ca.

Ligation-Dependent Picosecond Dynamics in Human Hemoglobin As Revealed by Quasielastic Neutron Scattering.

Hemoglobin, the vital O carrier in red blood cells, has long served as a classic example of an allosteric protein. Although high-resolution X-ray structural models are currently available for both the deoxy tense (T) and fully liganded relaxed (R) states of hemoglobin, much less is known about their dynamics, especially on the picosecond to subnanosecond time scales. Here, we investigate the picosecond dynamics of the deoxy and CO forms of human hemoglobin using quasielastic neutron scattering under near physiological conditions in order to extract the dynamics changes upon ligation.

Polar rotor scattering as atomic-level origin of low mobility and thermal conductivity of perovskite CHNHPbI.

Perovskite CHNHPbI exhibits outstanding photovoltaic performances, but the understanding of the atomic motions remains inadequate even though they take a fundamental role in transport properties. Here, we present a complete atomic dynamic picture consisting of molecular jumping rotational modes and phonons, which is established by carrying out high-resolution time-of-flight quasi-elastic and inelastic neutron scattering measurements in a wide energy window ranging from 0.0036 to 54 meV on a large single crystal sample, respectively.

Relaxation in a Prototype Ionic Liquid: Influence of Water on the Dynamics.

The influence of water on the relaxation of a prototype ionic liquid (IL) CmimBF is examined in the IL-rich regime combining quasi-elastic neutron scattering (QENS) and molecular dynamics (MD) simulations. The QENS and MD simulations results for relaxation of IL and the equimolar mixture with water probed by the dynamics of the Cmim hydrogen atoms in the time range of 2 ps to 1 ns are in excellent agreement. The QENS data show that translational relaxation increases by a factor of 7 on the addition of water, while rotational relaxation involving multiple processes fitted by a KWW function with low β values is speeded up by a factor of 3 on the time scale of QENS measurements.

Dynamical Behavior of Human α-Synuclein Studied by Quasielastic Neutron Scattering.

α-synuclein (αSyn) is a protein consisting of 140 amino acid residues and is abundant in the presynaptic nerve terminals in the brain. Although its precise function is unknown, the filamentous aggregates (amyloid fibrils) of αSyn have been shown to be involved in the pathogenesis of Parkinson's disease, which is a progressive neurodegenerative disorder. To understand the pathogenesis mechanism of this disease, the mechanism of the amyloid fibril formation of αSyn must be elucidated.

Molecular weight dependence of mean square displacement in ultrathin polymer films as studied by inelastic neutron scattering.

In previous papers, we found that the mean square displacement [u(2)] in polystyrene thin films decreased with film thickness and discussed two possible causes for the decrease. One is the hard interface layer between the polymer thin film and the substrate, and the other is the spatial confinement effect of polymer chains. In order to disclose the cause of the decrease of [u(2)] with film thickness, we studied the molecular weight M(w) dependence of [u(2)] in polystyrene thin films.

Lattice dynamics of the Zn-Mg-Sc icosahedral quasicrystal and its Zn-Sc periodic 1/1 approximant.

Quasicrystals are long-range-ordered materials that lack translational invariance, so the study of their physical properties remains a challenging problem. Here, we have carried out inelastic-X-ray- and neutron-scattering experiments on single-grain samples of the Zn-Mg-Sc icosahedral quasicrystal and of the Zn-Sc periodic cubic 1/1 approximant, with the aim of studying the respective influence of the local order and of the long-range order (periodic or quasiperiodic) on lattice dynamics. Besides the overall similarities and the existence of a pseudo-gap in the transverse dispersion relation, marked differences are observed, the pseudo-gap being larger and better defined in the approximant than in the quasicrystal.

Low-energy excitations and the fast process of polystyrene thin supported films studied by inelastic and quasielastic neutron scattering.

We studied the low-energy excitations in the meV region as well as the picosecond fast process in polystyrene thin supported films using inelastic and quasielastic neutron scattering in a temperature range from 11 to 430 K , covering the bulk glass transition temperature Tg. It was found that the mean square displacement u2 decreased with the film thickness below and above the glass transition temperature Tg, suggesting that the hardening occurs with decreasing the film thickness. Corresponding to the decrease in u2, it was also found that the density of phonon states G(omega) decreased with film thickness.

Inelastic neutron scattering study of low energy excitations in polymer thin films.

We report inelastic neutron scattering measurements on polystyrene thin films in a glassy state in the meV region. We found in elastic scattering that the mean square displacement decreased with film thickness, and hence the corresponding force constant f increased. In inelastic and quasielastic scattering, we observed the so-called boson peak at around 1.