Publications by authors named "Kaoru Hirai"
Article Synopsis
- Family-based treatment (FBT) is an effective method for treating anorexia nervosa (AN) in children and adolescents, but its application in Japan is limited due to specific guidelines and family involvement requirements.
- A 14-year-old girl with AN was hospitalized for malnutrition and dehydration, where she began modified FBT and continued it as an outpatient, achieving remission after a year.
- This case suggests that starting FBT during hospitalization can be beneficial for severe AN cases, highlighting the need for cultural adaptations of FBT to improve its accessibility.
Rationale: Ornithine transcarbamylase (OTC) deficiency, a urea cycle disorder, is a rare congenital metabolic error that leads to hyperammonemia. Psychiatric symptoms of hyperammonemia are nonspecific and can cause autism spectrum disorder (ASD)-like symptoms and attention-deficit/hyperactivity disorder (ADHD)-like symptoms. Some studies report that OTC deficiency is often initially diagnosed as ASD or ADHD.
View Article and Find Full Text PDFPurpose: Internet addiction (IA) has become a global problem and is one of the most common reasons for children to be referred for intervention because IA results in social and educational dysfunction and conflict with parents. IA is associated with various comorbid psychiatric disorders, with notable association between IA and family factors. However, little is known about parental psychopathology.
View Article and Find Full Text PDFIrritability is one of the most common reasons for which children and adolescents are referred for psychiatric evaluation and care. However, clinical irritability is difficult to define; thus, its prevalence varies widely. Chronic irritability may be associated with sensory processing difficulties (SPD), but little is known about the relationship between these two factors in clinical populations.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the effectiveness and the biomarkers of a specific vaccine (CHP-NY-ESO-1) in patients with esophageal squamous cell carcinoma (ESCC) after surgery, focusing on recurrence-free survival and safety.
- Fifty-four patients who had undergone surgery and previous chemotherapy were randomized to either receive the vaccine or be part of a control group, and the two-year disease-free survival rates were similar between both groups.
- Notably, the vaccine prompted an IgG response in nearly all vaccinated patients, and high expression of the PIGR gene in tumor tissues was linked to improved patient outcomes, suggesting a significant role of PIGR in tumor immunity during the vaccination process.
Purpose: Shoplifting, prevalent in patients diagnosed with bulimia nervosa (BN), is a serious behavioral problem in eating disorder (ED) patients. However, little is known about its overall presence, etiology, and consequences. This study aimed to determine whether shoplifting occurs before or after the onset of ED and to investigate the prevalence and correlates of shoplifting in ED patients.
View Article and Find Full Text PDFPreschool-onset obsessive-compulsive disorder with complete remission.
Neuropsychiatr Dis Treat
July 2018
Early-onset obsessive-compulsive disorder (OCD) is more severe than later-onset OCD. There are no reports of any early-onset OCD patients being cured, especially with respect to preschoolers. In this case report, we describe the successful treatment and cure of a 6-year-old preschool girl with severe OCD since the age of 3.
View Article and Find Full Text PDFBackground: Previous methods to measure glycohemoglobin (GHb) have been time-consuming or imprecise; we therefore developed a new enzymatic assay for GHb.
Methods: Blood cells were first hemolyzed, and hemoglobin was digested with protease to yield fructosyl amino acid. Fructosyl amino acid oxidase acts on the fructosyl amino acid and generates hydrogen peroxide, which reacts with chromogens in the presence of peroxidase.