Publications by authors named "Kaori Yazawa"
Article Synopsis
- Genomic analysis of the BCG Tokyo 172 vaccine reveals the presence of two subclones (types I and II), with notable differences in their response to oxidative stress.
- Type I bacilli show greater resistance to hydrogen peroxide and higher antioxidative stress response, leading to better survival rates in macrophages compared to type II bacilli.
- The study emphasizes the importance of understanding these differences for improving the quality control and safety of the BCG Tokyo 172 vaccine, as type I bacilli dominate in vaccine lots (97.6% versus 2.4% for type II).
