Publications by authors named "Kaori Watanabe-Iwata"
Life Sci Alliance
December 2024
Article Synopsis
- - The amyloid β peptide (Aβ3pE-42), linked to Alzheimer's disease, is known to accumulate in the brain, and a therapeutic antibody called donanemab has shown promise in clinical trials for treating it.
- - Research indicates that Aβ3pE-42 is more stable than other variants and its accumulation is influenced by a deficiency in neprilysin, an enzyme that typically breaks down Aβ, which leads to its selective deposition in mouse models.
- - The study suggests that treatments targeting Aβ3pE-42 may be more successful if administered prior to its accumulation in the brain, highlighting the importance of timing in anti-Aβ therapies.
