Use of the structure-function relationship in detecting glaucoma progression in early glaucoma.

Background: To evaluate the use of optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness and visual field (VF) measurements in detecting disease progression in patients with early glaucoma.

Methods: Over a 3-year period, this study examined 60 eyes of 39 glaucoma patients whose total deviation in the superior or inferior hemifield was more than -6 dB. All eyes underwent at least four serial RNFL measurements performed by Cirrus OCT, with the first and last measurements separated by at least three years.

Correlation between Intraocular Pressure Fluctuation with Postural Change and Postoperative Intraocular Pressure in Relation to the Time Course after Trabeculectomy.

Background. To investigate the correlation between intraocular pressure (IOP) fluctuation with postural change and IOP in relation to the time course after trabeculectomy. Methods.

Effect of the renin inhibitor aliskiren against retinal ischemia-reperfusion injury.

The purpose of this study was to investigate the effect of the renin inhibitor, aliskiren, on retinal ischemia-reperfusion injury. Retinal ischemia was induced by increasing intraocular pressure to 130 mmHg. At 7 days after ischemia, retinal damage was evaluated by measuring the retinal thickness and the number of retinal ganglion cells.

Evaluation of relationship between retinal nerve fiber layer thickness progression and visual field progression in patients with glaucoma.

Purpose: To evaluate the capability of optical coherence tomography (OCT), retinal nerve fiber layer (RNFL) thickness, and visual field (VF) measurements in glaucoma progression detection.

Methods: The study examined 62 eyes of 37 glaucoma patients observed over a 3-year period. All eyes underwent at least four serial RNFL measurements performed by Cirrus OCT, with the first and last measurements separated by at least 3 years.

Correlation between the ganglion cell-inner plexiform layer thickness measured with cirrus HD-OCT and macular visual field sensitivity measured with microperimetry.

Purpose: To evaluate relationships between the macular visual field (VF) mean sensitivity and the ganglion cell and inner plexiform layer (GCA) thicknesses.

Methods: Seventy-one glaucoma patients and 29 healthy subjects were included in this cross-sectional study. At each visit, GCA thicknesses were measured by Cirrus HD-OCT and static threshold perimetry was performed using Macular Integrity Assessment (MAIA).

Evaluation of peripapillary choroidal thickness in patients with normal-tension glaucoma.

Background: To compare peripapillary choroidal thickness measurements between normal and normal-tension glaucoma eyes.

Methods: Cross-sectional comparative study. 50 normal and 52 normal-tension glaucoma subjects were enrolled in the study.

Efficacy and safety of switching from topical latanoprost to bimatoprost in patients with normal-tension glaucoma.

Purpose: The aim of this study was to evaluate the efficacy and safety of bimatoprost in Japanese patients with normal-tension glaucoma (NTG) who showed insufficient response to latanoprost.

Methods: A prospective, nonrandomized study was conducted in patients with NTG, with ≤20% intraocular pressure (IOP) decrease from pretreatment baseline with latanoprost monotherapy who had been switched to bimatoprost. The IOP was measured at 4, 8, and 12 weeks after the switch to bimatoprost.

One-year results of reduced-fluence photodynamic therapy for polypoidal choroidal vasculopathy.

Purpose: To report 1-year results of reduced-fluence photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV) in Japanese patients.

Design: Prospective interventional case series.

Methods: In the present study, 28 treatment-naïve eyes of 28 consecutive patients underwent PDT with a reduced laser fluence of 25 J/cm(2).