Publications by authors named "Kaori Nagai"
Mucin-type O-glycosylation of serine or threonine residue in proteins is known to be one of the major post-translational modifications. In this study, two novel alkyl glycosides, N-lauryl-O-(2-acetamido-2-deoxy-α-d-galactopyranosyl)-l-serineamide (GalNAc-Ser-C12) and N-lauryl-O-(2-acetamido-2-deoxy-α-d-galactopyranosyl)-l-threonineamide (GalNAc-Thr-C12) were synthesized as saccharide primers to prime mucin-type O-glycan biosynthesis in cells. Upon incubating human gastric cancer MKN45 cells with the saccharide primers, 22 glycosylated products were obtained, and their structures were analyzed using liquid chromatography-mass spectrometry and enzyme digestion.
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- The study aimed to assess the quality of reporting in randomized controlled trials (RCTs) of antiretroviral therapy (ART) for HIV/AIDS, emphasizing the need for clear methodology and result transparency for proper evaluation.
- Researchers analyzed original RCT articles from PubMed, categorizing them based on publication years relative to the CONSORT guidelines and evaluating them against specific reporting criteria.
- Findings showed an improvement in reporting rates over time, with an overall adherence rate of about 70%, though some critical areas, like protocol changes and randomization details, still had low reporting rates.