Publications by authors named "Kaori Hosoi"

Article Synopsis
  • SNARE proteins play a crucial role in membrane fusion by assembling into complexes on target membranes and transport vesicles.
  • NSF and α-SNAP help disassemble these complexes for reuse, but the function of γ-SNAP in this process was previously unclear.
  • This study reveals that γ-SNAP regulates the trafficking of specific proteins like the EGF receptor and transferrin in endosomes, affecting their distribution and degradation within cells.
View Article and Find Full Text PDF

In order to examine the relationship between the intention to stay on the job and job satisfaction among Japanese nurses, and to obtain clues for preventing turnover, we conducted a questionnaire survey. The subjects involved in the survey included 625 female nurses (registered nurses, licensed practical nurses and assistant nurses) working in 4 small and medium-sized private hospitals, excluding directors of nursing. Of the 625 questionnaires distributed, 556 (89.

View Article and Find Full Text PDF

Background: Hydrofluoroalkane-134a (HFA) has been shown to be a safe replacement for chlorofluorocarbons (CFCs) as a pharmaceutical propellant, with the advantage that it has no ozone-depleting potential. This is the first report of the pharmacokinetics of beclomethasone dipropionate (BDP) delivered from a pressurized solution formulation using an HFA propellant system (HFA-BDP) in Japanese children with bronchial asthma.

Methods: Plasma concentrations of beclomethasone 17-monopropionate (17-BMP),a major metabolite of BDP, following an inhaled dose of HFA-BDP (200 microg as four inhalations from 50 microg/actuation) in five Japanese children with bronchial asthma were quantified and analyzed by a non-compartmental analysis to obtain pharmacokinetic parameters.

View Article and Find Full Text PDF

Pleuropulmonary blastoma (PPB) is a rare and aggressive primary intrathoracic neoplasma of children. The prognosis is extremely poor with frequent metastasis to the brain and bone. We present a 4-year-old girl with a tumor mass in the right hemithorax initially diagnosed as pneumoniae.

View Article and Find Full Text PDF

Objectives: The objective of this study was to evaluate factors associated with turnover intention among nurses in small and medium-sized medical institutions.

Methods: A self-administered questionaire survey was performed in 293 registered nurses, licensed practical nurses, and assistant nurses working full-time in various medical institutions. Multiple linear regression analysis was conducted, with turnover intention as the dependent variable, and nurses' basic attributes and job satisfaction as independent variables.

View Article and Find Full Text PDF

Objectives: Previous types of rock wool has been recently replaced with high-temperature wool (HT wool). HT wool is characterized by a chemical composition with a higher concentration of Al(2)O(3) and a lower concentration of SiO(2), lower biopersistence, and a higher melting point than previous types of rock wool. To evaluate the safety of HT wool, an asbestos substitute, we examined the biopersistence of HT wool in the lungs, based on changes in fiber count according to the length and fiber size (length and width), by performing a nose-only inhalation exposure study in rats.

View Article and Find Full Text PDF

To improve the satisfaction of people who had periodical worksite health check-ups, we conducted a questionnaire survey. It is possible that a portion of the health check-up participants who have a medical history of serious disease may have different expectations of periodical health check-ups compared to healthy individuals. We conducted the analysis by dividing the participants into three groups: those with a medical history of serious disease, those without a medical history of serious disease, and the whole group of those with and without a medical history of serious disease.

View Article and Find Full Text PDF