Publications by authors named "Kaori Fujimaki"
Regulatory T (Treg) cells, which are essential for maintaining self-tolerance, inhibit anti-tumor immunity, consequently hindering protective cancer immunosurveillance, and hampering effective anti-tumor immune responses in tumor-bearing hosts. Here, we show that depletion of Treg cells via targeting glycoprotein A repetitions predominant (GARP) induces effective anti-tumor immune responses. GARP was specifically expressed by highly suppressive Treg cells in the tumor microenvironment (TME) of multiple cancer types in humans.
View Article and Find Full Text PDFArticle Synopsis
- Tumor neoantigens, which arise from genetic changes, can be targeted by T-cells to fight cancer, but tumors often develop ways to escape immune detection.
- Researchers used a gene expression system to induce neoantigens in colorectal and melanoma cancer cell lines, finding that this led to significant tumor growth inhibition, especially relying on CD8+ T-cells.
- Additionally, combining neoantigen induction with PD-1/PD-L1 blockade further improved the antitumor response, suggesting this strategy could help overcome resistance to existing cancer therapies.