Publications by authors named "Kanthimani Phanwichien"
Promotion of aflatoxin B1-induced hepatocarcinogenesis by dichlorodiphenyl trichloroethane (DDT).
Southeast Asian J Trop Med Public Health
September 2002
Article Synopsis
- The study investigates how DDT affects liver cancer development in rats that have been exposed to aflatoxin B1 (AFB1).
- In the first experiment, rats exposed to both AFB1 and DDT showed a higher number of neoplastic nodules compared to those only given AFB1.
- The second experiment indicated that rats exposed to AFB1 followed by a higher DDT dosage developed more altered liver foci and tumors over time, suggesting that DDT slightly increases the cancer risk associated with AFB1 exposure.
- Overall, the findings highlight a potential interaction between DDT and AFB1 that may enhance hepatocarcinogenesis.