Publications by authors named "Kansuke Hasunuma"
Article Synopsis
- The study focuses on how the sexual receptivity of female mice, measured by the lordosis response, is regulated by estrogen receptors, specifically ERα and ERβ, during different days of the estrous cycle.
- It highlights the crucial role of ERα in activating lordosis on the day of estrus (Day 1) and investigates the role of ERβ in the dorsal raphe nucleus (DRN) during the nonreceptive state on Day 2.
- Results indicate that activated DRN-ERβ neurons contribute to a decline in lordosis on Day 2, suggesting that these neurons inhibit receptivity when stimulated, providing insight into the hormonal regulation of sexual behaviors.
17β-estradiol (E2) regulates various forms of social behavior through the activation of two types of estrogen receptors, ERα and ERβ. The lateral septum (LS) is thought to be one of the potential target sites of E2, but the role played by ERα and ERβ in this brain area remains largely unknown. In the present study, we first analyzed the distribution of ERα and ERβ with double fluorescent immunohistochemistry in a transgenic mouse line in which red fluorescent protein (RFP) signal has been a reliable marker of ERβ expression.
View Article and Find Full Text PDF