Publications by authors named "Kanokporn Sathiandee"
Article Synopsis
- A study was conducted among HIV patients not previously treated with drugs at a hospital in Burkina Faso, aiming to analyze their clinical and viral data before and after the start of widespread antiretroviral therapy (ART).
- The analysis showed the presence of various HIV subtypes, primarily CRF06_cpx (44.2%) and CRF02_AG (37.5%), with a notable primary drug resistance mutation prevalence of 12.5% largely seen in reverse transcriptase sequences, affecting treatment options.
- The study highlighted that drug resistance mutations were similar across key HIV subtypes and raised concerns about potential virus transmission and the impact of prior but unrecorded ART use.
Objective: Determine the pattern of drug resistance among HIV infected drug exposed patients failing therapy in Ouagadougou, Burkina Faso.
Methods: The protease (PR) and reverse transcriptase (RT) of 87 samples from 75 treatment exposed HIV infected patients failing therapy were PCR amplified, sequenced, subtyped and analyzed for the presence of drug resistance mutations.
Results: The most common drugs used were 3TC, AZT (or d4T) and EFV.
: On introduction of a program for prevention of mother-to-child transmission (PMTCT) of HIV in Nouna, rural Burkina Faso, we determined HIV prevalence in this region to be 3.6%, which is significantly lower than the 7% reported for 2 major cities of Burkina Faso. Forty-three samples from drug-naive pregnant women and patients before introduction of antiretroviral therapy (ART) were genotypically characterized in gag, pol, and env regions.
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