Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism.

Alterations to the excitation/inhibition (E/I) ratio are postulated to underlie behavioral phenotypes in autism spectrum disorder (ASD) patients and mouse models. However, in wild type mice the E/I ratio is not constant, but instead oscillates across the 24-h day. Therefore, we tested whether E/I regulation, rather than the overall E/I ratio, is disrupted in two ASD-related mouse lines: KO and BTBR, models of syndromic and idiopathic ASD, respectively.

Learning curve and proficiency assessment for gynecological brachytherapy amongst radiation oncology trainees in India: Results from a prospective study.

Purpose: The quality of cervical cancer intracavitary brachytherapy (ICBT) depends on the training and experience of the radiation oncologist (RO). The present study was performed to establish primary learning curve for ICBT.

Materials And Methods: Forty-three skill parameters were identified for performing ICBT and were included for Brachytherapy Proficiency Assessment and Scoring System (Brachy-PASS) questionnaire.

Machine learning boosts wind turbine efficiency with smart failure detection and strategic placement.

The research study objective seeks to improve the efficiency of wind turbines using state-of-the-art techniques in the domain of ML, making wind energy the key player in fashioning a favorable future. Wind Turbine Health Monitoring (WTHM) is typically achieved through either vibration analysis or by using Supervisory Control and Data Acquisition (SCADA) data of wind turbines, wherein conventional fault pattern identification is a time-consuming, guesswork process. This work proposed an intelligent automated approach to early fault detection through the implementation of the HARO (Huber Adam Regression Optimizer) model, which combines Transformer networks with Lasso Regression and the Adam optimizer.

Letter to the Editor: In Response to the Retraction Notice of an Article.

Kannan S. Letter to the Editor: In Response to the Retraction Notice of an Article. Indian J Crit Care Med 2024;28(12):1184.

Sleep disorders in functional neurological disorder - a systematic review and meta-analysis.

Introduction: Functional neurological disorders (FND) are conditions marked by disruptions in brain network function without structural abnormalities. Sleep disturbances, though under-researched, are commonly observed in FND patients and may worsen symptoms and overall health.

Methods: This systematic review had been registered prospectively in PROSPERO with the registration number: CRD42023446306.

Stilbene-based fluorescent chemosensor for selective detection of cyanide ion in DMSO medium and its application in cell-imaging, fingerprint, and food sample analysis.

We designed a new cyanide sensing probe by one-step synthesis and evaluated it using UV-vis and fluorescent techniques. The active moiety of (Z)-3-(4-(methylthio) phenyl)-2-(4-nitrophenyl) acrylonitrile (NCS) demonstrated fluorescence. The probe NCS showed turn-off fluorescence in the presence of cyanide (CN¯), which has a higher selectivity and sensitivity than other anions.

Enhanced human activity recognition in medical emergencies using a hybrid deep CNN and bi-directional LSTM model with wearable sensors.

Human activity recognition (HAR) is one of the most important segments of technology advancement in applications of smart devices, healthcare systems & fitness. HAR uses details from wearable sensors that capture the way human beings move or engage with their surrounding. Several researchers have thus presented different ways of modeling human motion, and some have been as follows: Many researchers have presented different methods of modeling human movements.

Evaluation of the Articular Disc Using the Magnetic Resonance Cartigram in Asymptomatic and Symptomatic Temporomandibular Disorders.

 The study is aimed to perform magnetic resonance (MR) cartigram of the articular disc in patients with asymptomatic and symptomatic temporomandibular disorders (TMD).  Thirty-nine volunteers were divided into three groups: 16 symptomatic TMD, 16 asymptomatic TMD, and 7 controls. The articular disc was divided into three segments (anterior, middle, and posterior) and analyzed using morphological magnetic resonance imaging (MRI) and T2 mapping sequences.

Selective Adipose Cryolysis for Reduction of Lingual Tissue in a Porcine Model.

Objectives: Oropharyngeal fat volume is associated with obstructive sleep apnea (OSA) severity. Selective adipose cryolysis may produce cold-induced adipose cell death while sparing surrounding tissues. This study explored (1) similarities in tongue fat between porcine and human models and (2) the feasibility and potential reduction of lingual fat using selective adipose cryolysis.

Therapeutically-Induced Lymphangiogenesis is Ineffective in Resolving Established Kidney Disease in Mice.

Background: Chronic kidney disease (CKD) counts acute kidney injuries (AKI) as one of its many underlying causes. Lymphatic vessels are important in modulating inflammation post-injury. Manipulating lymphatic vessel expansion thus has the potential to alter CKD progression.

TERT promoter mutations in gliomas: Molecular roles in tumorigenesis, metastasis, diagnosis, prognosis, therapeutic targeting, and drug resistance.

Telomerase reverse transcriptase (TERT), a critical player in cellular immortalization, has emerged as a focal point of investigation due to its frequent promoter mutations in various human malignancies. TERT promoter mutations exhibit a significant role in tumorigenesis, fostering unbridled cellular proliferation and survival. This comprehensive review delves into the landscape of TERT promoter mutations and their profound implications in cancer, particularly within the context of gliomas.

Two decades of continuous progresses and breakthroughs in the field of bioactive ceramics and glasses driven by CICECO-hub scientists.

Over the past two decades, the CICECO-hub scientists have devoted substantial efforts to advancing bioactive inorganic materials based on calcium phosphates and alkali-free bioactive glasses. A key focus has been the deliberate incorporation of therapeutic ions like Mg, Sr, Zn, Mn, or Ga to enhance osteointegration and vascularization, confer antioxidant properties, and impart antimicrobial effects, marking significant contributions to the field of biomaterials and bone tissue engineering. Such an approach is expected to circumvent the uncertainties posed by methods relying on growth factors, such as bone morphogenetic proteins, parathyroid hormone, and platelet-rich plasma, along with their associated high costs and potential adverse side effects.

Sublingual glyceryl trinitrate given during adenosine sestamibi myocardial perfusion imaging causes apparent transient ischaemic dilation in a propensity-matched analysis.

Objectives: Administration of sublingual glyceryl trinitrate (GTN) prior to resting radiotracer injection during myocardial perfusion imaging (MPI) has been advocated to aid detection of viable myocardium and increase the extent of reversible perfusion defects. However, GTN is also known to reduce resting left ventricular volume and could thus increase the transient ischaemic dilation (TID) ratio, independently of severe or extensive coronary artery disease. We aimed to determine if GTN administration causes an increase in the TID ratio.

Anti-leukemia efficacy of the dual BCL2/BCL-XL inhibitor AZD0466 in acute lymphoblastic leukemia preclinical models.

The upregulation of BCL2 and BCL-XL, two proteins in the BCL2 family of proteins, leads to a disproportional expression of pro-death and pro-survival proteins in favor of leukemia survival, tumorigenesis, and chemoresistance. In different subsets of acute lymphoblastic leukemia (ALL), the proportion of these two proteins varies, and their potential as therapeutic targets needs detailed characterization. Here, we investigated BCL2 and BCL-XL, the genes that encode BCL2 and BCL-XL, and their expression differences between B-cell acute lymphoblastic leukemia (B-ALL) and T-cell ALL (T-ALL).

Cellular stress response and neuroprotection of flavonoids in neurodegenerative diseases: Clinical insights into targeted therapy and molecular signaling pathways.

Neurodegenerative diseases (NDs) are caused by the gradual decline of neuronal structure and function, which presents significant challenges in treatment. Cellular stress responses significantly impact the pathophysiology of these disorders, often exacerbating neuronal damage. Plant-derived flavonoids have demonstrated potential as neuroprotective agents due to their potent anti-inflammatory, anti-apoptotic, and antioxidant properties.

Database resources of the National Center for Biotechnology Information in 2025.

The National Center for Biotechnology Information (NCBI) provides online information resources for biology, including the GenBank® nucleic acid sequence repository and the PubMed® repository of citations and abstracts published in life science journals. NCBI provides search and retrieval operations for most of these data from 31 distinct repositories and knowledgebases. The E-utilities serve as the programming interface for most of these.

High willingness-to-taste in UK children aged 4-7 years was driven by contextual facilitation, not intervention, in a randomized controlled trial of sensory food education.

Many children would benefit from a diet richer in vegetables and fruit. Reluctance to taste new foods is widely recognized as a barrier to healthy dietary variety in children. 'Flavour School' is a programme of 'sensory food education', aiming to increase children's confidence and curiosity in exploring foods and flavours, especially vegetables and fruit.

Residential food environment and dietary antioxidant consumption among pregnant women: Modifying effects of socioeconomic factors and ethnic identity.

Background: Residential food environment influences dietary patterns, however the impact of individuals' perceived social identity on their antioxidant intake, an indicator of healthy dietary patterns, remains underexplored.

Objective: We conducted a cross-sectional analysis using data collected in a longitudinal cohort. In the study, we aimed to investigate the interactions between the food environment and two indicators of social identity, specifically a subjective ladder measure of socioeconomic status (SES) and the Multigroup Ethnic Identity Measure (MEIM) score, in relation to dietary antioxidant intake (DAI) among n = 512 Boston and NYC-resident pregnant women.