Spontaneous detection of F and viscosity using a multifunctional tetraphenylethene-lepidine probe: Exploring environmental applications.

Excessive fluoride ions (F) in drinking water and food is harmful for human health and the environment. Therefore, a fluorescent probe tetraphenylethylene-quinoline (P-1) is developed with multiple sensing properties for the sequential detection of tert-butyldiphenylsilyl chloride (TBDS), F, and viscosity. Sensor P-1 first recognized TBDS and then observed an intramolecular charge transfer process, which produced an intermediate sensor P-2 in addition to fluorescence quenching at 576 nm.

Rational construction of porous cobalt nanoparticle integrated nitrogen doped hollow carbon nanostructures for peptide agonist exendin-4 biosensing.

In this study, we designed a point-of-care (POC) testing electrochemical biosensor using an integrated biosensing assay based on hollow-like nitrogen-doped carbon nanostructures combined with cobalt nanoparticles (Co@HNCNs, CoO@HNCNs, and CoP@HNCNs). These are functionalized with Anti-Exendin-4 Antibodies (Anti-Ex-4-Abs) and Bovine Serum Albumin (BSA) to create sensitive probes (Co@HNCNs/Anti-Ex-4-Abs/BSA, CoO@HNCNs/Anti-Ex-4-Abs/BSA, and CoP@HNCNs/Anti-Ex-4-Abs/BSA) for the ultrasensitive detection of exendin-4 (Ex-4), a peptide agonist used in the treatment of type 2 diabetes mellitus (T2DM). Among the cobalt-based carbon nanostructures, the CoO@HNCNs/Anti-Ex-4-Abs/BSA nanoprobe demonstrated superior ability to specifically recognize Ex-4.

Multifunctional Sensors for Successive Detection of Endogenous ONOO and Mitochondrial Viscosity: Discriminating Normal to Cancer Models.

Diagnosing cancer in its early stages can play an important role in prolonging the lifespan of patients, which demands the use of powerful tools to detect biomarkers accurately. However, since most fluorescent probes described for cancer diagnosis are limited to recognizing a single molecule, achieving the high accuracy criteria remains difficult. Here, sensor is constructed for the sequential detection of , ONOO, and viscosity.

Synthesis of novel nanoflowers-like P, K co-doped graphitic carbon nitride for efficient HO photoproduction.

Photocatalytic oxygen reduction is considered an economical and green way to produce HO. Graphitic carbon nitride is a common photocatalyst, but its activity is limited by the low specific surface area and the high recombination rate of photogenerated electron-hole pairs. Herein, nanoflowers-like phosphorus (P) and potassium (K) co-doped graphitic carbon nitride (PKCN) is synthesized by co-polymerization of ammonium dihydrogen phosphate and melamine in the mixed molten salt (KCl/LiCl) medium.

Efficient photocatalytic HO production and photodegradation of RhB over K-doped g-CN/ZnO S-scheme heterojunction.

Designing efficient dual-functional catalysts for photocatalytic oxygen reduction to produce hydrogen peroxide (HO) and photodegradation of dye pollutants is challenging. In this work, we designed and fabricated an S-scheme heterojunction (g-CN/ZnO composite photocatalyst) via one-pot calcination of a mixture of ZIF-8 and melamine in the KCl/LiCl molten salt medium. The KCN/ZnO composite produced 4.

Revolutionizing Glucose Monitoring: Enzyme-Free 2D-MoS Nanostructures for Ultra-Sensitive Glucose Sensors with Real-Time Health-Monitoring Capabilities.

The growing requirement for real-time monitoring of health factors such as heart rate, temperature, and blood glucose levels has resulted in an increase in demand for electrochemical sensors. This study focuses on enzyme-free glucose sensors based on 2D-MoS nanostructures explored by simple hydrothermal route. The 2D-MoS nanostructures were characterized by powder X-ray diffraction, energy-dispersive X-ray spectroscopy, scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, and XPS techniques and were immobilized at GCE to obtain MoS-GCE interface.

Efficient photocatalytic hydrogen peroxide production over S-scheme InS/molten salt modified CN heterojunction.

Graphitic phase carbon nitride (g-CN), as a novel n-type metal-free material, is employed as a visible light-receptive catalyst because of its narrow band gap and abundant nitrogen. To overcome the low carrier mobility efficiency of g-CN, its modification by K ions was adopted. In addition, InS was selected to couple with modified g-CN to overcome the recombination of photogenerated e/h.

Dual-channel fluorescent probe for discriminative detection of HS and NH: Exploring sensing mechanism and real-time applications.

A highly efficient system incorporates the real-time visualization of the two toxic molecules (HS and NH) and the recognition of corresponding transforms using a fluorescent sensor. In this paper, a dual-responsive probe (QS-DNP) based on methylquinolinium-salicyaldehyde-2,4-dinitrophenyl was developed that can simultaneously detect HS and NH at two independent fluorescent channels without signal crosstalk. QS-DNP showed excellent anti-interference, high selectivity, outstanding water solubility, low LOD values (HS: 51 nM; NH: 40 nM), low cytotoxicity, and mitochondrial localization properties.

Lemon extract supported green synthesis of bimetallic CuO/Ag nanoporous materials for sensitive detection of vitamin D3.

In modern era, deficiency of Vitamin D3 is predominantly due to limited exposure to sunlight and UV radiation resulting from indoor lifestyles. Several studies have revealed that vitamin D deficiency can lead to chronic vascular inflammation, diabetes mellitus, hypertension, congestive left ventricular hypertrophy, and heart failure. This study introduces a green synthesis of novel bimetallic nanoporous composite, CuO/Ag using lemon extract.

Quinoline-derived electron-donating/withdrawing fluorophores for hydrazine detection and applications in environment and bioimaging.

Substitution can be employed to competently tune the photophysical properties of chemosensors. The effect of substituents on the absorption and emission properties of quinoline probes was investigated. Therefore, salicylaldehyde (S), N-diethylamino-salicylaldehyde (D), and nitro-salicylaldehyde (W)-based quinoline Schiff base derivatives were investigated with hydrazine and studied for their photophysical properties.

Metal Oxides Nanomaterials and Nanocomposite-Based Electrochemical Sensors for Healthcare Applications.

Wide-ranging research efforts have been directed to prioritize scientific and technological inventions for healthcare monitoring. In recent years, the effective utilization of functional nanomaterials in various electroanalytical measurements realized a rapid, sensitive, and selective detection and monitoring of a wide range of biomarkers in body fluids. Owing to good biocompatibility, high organic capturing ability, strong electrocatalytic activity, and high robustness, transition metal oxide-derived nanocomposites have led to enhancements in sensing performances.

Carbon Nanocomposites-based Electrochemical Sensors and Biosensors for Biomedical Diagnostics.

Detection of emergent biomolecules or biomarkers remains crucial for early diagnosis in advancing healthcare monitoring and biomedicine. The possibility for rapid detection, real-time monitoring, high sensitivity, low detection limit, good selectivity, and low cost is central, among other significant issues for advancing point-of-care diagnosis. Carbon-based nanocomposites have been employed as sensing materials for various biomarkers due to their high surface-to-volume ratio, high electrical conductivity, chemical stability, and biocompatibility.

Nanostructured biosensing platforms for the detection of food- and water-borne pathogenic Escherichia coli.

Pathogenic bacterial infection is one of the principal causes affecting human health and ecosystems. The accurate identification of bacteria in food and water samples is of significant interests to maintain safety and health for humans. Culture-based tests are practically tedious and may produce false-positive results, while viable but non-culturable microorganisms (NCMs) cannot be retrieved.

Gold Nanoclusters Dispersed on Gold Dendrite-Based Carbon Fibre Microelectrodes for the Sensitive Detection of Nitric Oxide in Human Serum.

Herein, gold nanoclusters (Au NC) dispersed on gold dendrite (Au DS)-based flexible carbon fibre (AuNC@AuDS|CF) microelectrodes are developed using a one-step electrochemical approach. The as-fabricated AuNC@AuDS|CF microelectrodes work as the prospective electrode materials for the sensitive detection of nitric oxide (NO) in a 0.1 M phosphate buffer (PB) solution.

Facile synthesis of NiAlO/g-CN composite for efficient photocatalytic degradation of tetracycline.

Designing high-efficiency photocatalysts responsive to visible light is important for the degradation of antibiotics in water. Heterojunction engineering is undoubtedly an effective strategy to improve the photocatalytic performance. In this work, spinel-type metal oxides (NiAlO, NAO) are synthesized by a simple sol-gel and calcination process.

Nanostructured Transition Metal Sulfide-based Glucose and Lactic Acid Electrochemical Sensors for Clinical Applications.

Engineered nanostructures of mixed transition metal sulfides have emerged as promising nanomaterials (NMs) for various electrochemical sensors and biosensors applications, including glucose sensors (GS) and lactic acid sensors (LAS) in clinical aspects. Electrochemical sensors based on nanostructured materials, such as transition metal sulfides and their nanocomposites, including graphene, carbon nanotubes, molecularly imprinted polymers, and metal-organic frameworks, have emerged as potent tools for the monitoring and quantification of biomolecules. Highly sensitive and selective electrochemical detection systems have generally been established credibly by providing new functional surfaces, miniaturization processes, and different nanostructured materials with exceptional characteristics.

NiP Nanoparticle-Inserted Porous Layered NiO Hetero-Structured Nanosheets as a Durable Catalyst for the Electro-Oxidation of Urea.

The electro-oxidation of urea (EOU) is a remarkable but challenging sustainable technology, which largely needs a reduced electro-chemical potential, that demonstrates the ability to remove a notable harmful material from wastewater and/or transform the excretory product of humans into treasure. In this work, an NiP-nanoparticle-integrated porous nickel oxide (NiO) hetero-structured nanosheet (NiP@NiO/NiF) catalyst was synthesized through in situ acid etching and a gas-phase phosphating process. The as-synthesized NiP@NiO/NiF catalyst sample was then used to enhance the electro-oxidation reaction of urea with a higher urea oxidation response (50 mA cm at 1.

Bimetallic Nanomaterials-Based Electrochemical Biosensor Platforms for Clinical Applications.

Diabetes is a foremost health issue that results in ~4 million deaths every year and ~170 million people suffering globally. Though there is no treatment for diabetes yet, the blood glucose level of diabetic patients should be checked closely to avoid further problems. Screening glucose in blood has become a vital requirement, and thus the fabrication of advanced and sensitive blood sugar detection methodologies for clinical analysis and individual care.

Co Nanoparticle-Encapsulated Nitrogen-Doped Carbon Nanotubes as an Efficient and Robust Catalyst for Electro-Oxidation of Hydrazine.

Structural engineering is an effective methodology for the tailoring of the quantities of active sites in nanostructured materials for fuel cell applications. In the present study, Co nanoparticles were incorporated into the network of 3D nitrogen-doped carbon tubes (Co@NCNTs) that were obtained via the molten-salt synthetic approach at 800 °C. Morphological representation reveals that the Co@NCNTs are encompassed with Co nanoparticles on the surface of the mesoporous walls of the carbon nanotubes, which offers a significant active surface area for electrochemical reactions.

A universal strategy for the incorporation of internal standards into SERS substrates to improve the reproducibility of Raman signals.

The uneven distribution of metal nanoparticles is a vital influencing factor in the poor uniformity of surface-enhanced Raman scattering (SERS) substrates, which is a challenge in SERS quantitative analysis. Recent reports showed that the reproducibility of a nonuniform SERS substrate can be effectively improved by the use of an internal standard (IS). However, most of these approaches require the investment of time for precise regulation, and those approaches based on the addition of an IS are specific to a certain substrate.

Surface-enhanced electrochemiluminescence combined with resonance energy transfer for sensitive carcinoembryonic antigen detection in exhaled breath condensates.

The detection of biomarkers in exhaled breath condensates (EBCs) is regarded as a promising non-invasive diagnostic approach. However, the ultralow concentration of biomarkers in EBCs is a great challenge. Herein, a sensitive dual signal amplification strategy was developed based on surface-enhanced electrochemiluminescence (SEECL) combined with resonance energy transfer (RET).

Core-satellite assemblies and exonuclease assisted double amplification strategy for ultrasensitive SERS detection of biotoxin.

In this work, core-satellite assemblies and exonuclease assisted double amplification strategy is developed to produce surface-enhanced Raman scattering (SERS) biosensor towards ultrasensitive detection of biotoxin. In the presence of target molecules, the exonuclease III (Exo III) assisted efficient recycling amplification provides an excellent pathway for the fabrication of core-satellite SERS sensor. Briefly, the proposed strategy includes the following double amplifications: (i) Exo III induced target-related signal amplification; (ii) core-satellite assemblies assisted formation of SERS "hot-spots" induced signal amplification.

Nickel-phosphate pompon flowers nanostructured network enables the sensitive detection of microRNA.

An electrochemical immuno-nanogenosensor is developed based on noble-metal-free nickel phosphate nanostructure (NiPNs) as an excellent biocompatible material for miRNA detection in blood serum and urine samples without using indicators for the first time. The pompon flower-like morphology of NiPNs is synthesized, and characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction pattern (XRD), fourier transform-infrared spectroscopy (FT-IR), and electrochemical impedance methods. The novel NiPNs nanostructured interface was constructed by coordinate covalent bonding between Ni and phosphate group of probe DNA.