Publications by authors named "Kanna Muramatsu"
Article Synopsis
- Most nanoparticles usually enter cells through endocytosis, getting trapped in endosomes that hinder their movement within the cell.
- Some materials, like cell-penetrating peptides (CPPs), can directly cross the cell membrane, which is a more efficient way to deliver drugs.
- The study shows that a specific type of random copolymer, p(DMAPS-ran-PEGMA), can enter cells by translocating through the membrane, and these polymers can effectively deliver drugs to specific cell parts, like mitochondria and the nucleus, which may help in cancer treatment.
Trading polymeric microspheres: exchanging DNA molecules via microsphere interaction.
Colloids Surf B Biointerfaces
April 2015
A new class of artificial molecular transport system is constructed by polymeric microspheres. The microspheres are prepared by self-assembly of poly(ethylene glycol)-block-poly(3-dimethyl(methacryloyloxyethyl)ammonium propane sulfonate), PEG-b-PDMAPS, by intermolecular dipole-dipole interaction of sulfobetaine side chains in water. Below the upper critical solution temperature (UCST) of PEG-b-PDMAPS, the microspheres (∼1μm) interact with other microspheres by partial and transit fusion.
View Article and Find Full Text PDFArticle Synopsis
- A double hydrophilic block copolymer, PEG-SB, is created using RAFT polymerization, featuring a unique structure with PEG and sulfonate side chains.
- The copolymer can form multi-layered microspheres, which interact through dipole-dipole forces and exhibit a controllable upper critical solution temperature (UCST).
- The microspheres can dissociate at high temperatures and reform into uniform 1 μm-sized particles upon cooling, with their behavior further modulated by NaCl concentration, highlighting its potential applications in nano-biotechnology.