Unsaturated fatty acids and a prenylated tryptophan derivative from a rare actinomycete of the genus .

A genome mining survey combined with metabolome analysis of publicly available strains identified sp. RD010705, a strain belonging to an underexplored genus of rare actinomycetes, as a producer of new metabolites. HPLC-DAD-guided fractionation of its fermentation extracts resulted in the isolation of five new methyl-branched unsaturated fatty acids, (2,4)-2,4-dimethyl-2,4-octadienoic acid (), (2,4)-2,4,7-trimethyl-2,4-octadienoic acid (), ()-(-)-phialomustin B (), (2,4)-7-hydroxy-2,4-dimethyl-2,4-octadienoic acid (), (2,4)-7-hydroxy-2,4,7-trimethyl-2,4-octadienoic acid (), and one prenylated tryptophan derivative, 6-(3,3-dimethylallyl)--acetyl-ʟ-tryptophan ().