Crystal structure of [3-amino-2-(phenyl-diazenyl)-pyridine]chlorido-(η(6)-p-cymene)-ruthenium(II) chloride.

The title compound, [RuCl(C10H14)(C11H10N4)]Cl is an Ru(II) complex in which an η (6) -p-cymene ligand, two N atoms of 3-amino-2-(phenyl-azo)pyridine and one Cl ion form a piano-stool coordination environment around the metal ion. In the crystal structure, N-H⋯Cl hydrogen bonds play an important role in the formation of the supramolecular zigzag chain along the a-axis direction. Disorder is observed for the isopropyl group with site-occupancy factors refined to 0.

Cellular responses of BRCA1-defective and triple-negative breast cancer cells and in vitro BRCA1 interactions induced by metallo-intercalator ruthenium(II) complexes containing chloro-substituted phenylazopyridine.

Background: Triple-negative breast cancer (TNBC) is defined by the absence of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. Breast cancers with a BRCA1 mutation are also frequently triple-negative. Currently, there is a lack of effective therapies and known specific molecular targets for this aggressive breast cancer subtype.

2-Amino-5-bromo-pyridin-1-ium (2-amino-5-bromo-pyridine-κN (1))trichloridozincate.

The structure of the title salt, (C5H6BrN2)[ZnCl3(C5H5BrN2)], consists of discrete 2-amino-5-bromo-pyridin-1-ium cations and distorted tetra-hedral (2-amino-5-bromo-pyridine)-tri-chlorido-zincate anions. In the crystal, the complex anions and cations are linked via N-H⋯Cl hydrogen bonds into layers parallel to (101). Short Br⋯Cl contacts of 3.

Bis[5-chloro-2-(phenyl-diazenyl-κN(2))pyridine-κN]bis-(thio-cyanato-κN)iron(II).

In the title complex, [Fe(NCS)(2)(C(11)H(8)ClN(3))(2)], the Fe(II) atom is coordinated by two N atoms from the thio-cyanate ligands and four N atoms from two chelating 5-chloro-2-(phenyl-diazen-yl)pyridine ligands, generating a fairly regular FeN(6) octa-hedral coordination geometry. The thio-cyanate ions are in a cis disposition and the pyridine N atoms are in a trans orientation. In the crystal, a short inter-molecular Cl⋯S contact [3.

Photoactive azoimine dyes: 4-(2-pyridylazo)-N,N-diethylaniline and 4-(2-pyridylazo)-N,N-dimethylaniline: computational and experimental investigation.

4-(2-Pyridylazo)-N,N-dimethylaniline and 4-(2-pyridylazo)-N,N-diethylaniline, two photoactive azoimine dyes, were prepared from the reaction of 2-aminopyridine with N,N-dialkyl-1,4-nitrosoaniline at room temperature. Structural characterizations of these dyes using single crystal X-ray diffraction, (1)H NMR, elemental analysis, mass spectroscopy and IR spectroscopy have been carried out. The X-ray structure indicates a trans configuration around the azo group.

N,N-Dimethyl-4-[(2-pyrid-yl)diazen-yl]aniline.

The title compound, C(13)H(14)N(4), adopts a trans configuration about the azo bond. There is a dihedral angle of 12.18 (7)° between the pyridine and benzene rings and the mean plane of the dimethyl-amino substituent is twisted by 6.

Crystal structure of bromo(2,2':6',2"-terpyridine)(2-(phenylazo)-pyridine)ruthenium(II) tetrafluoroborate.

The title compound, C26H20N6BrRu(BF4), crystallizes in the centrosymmetric space group P2(1)/n and consists of discrete complex units. The Ru(II) ion is octahedrally coordinated to one 2,2':6',2"-terpyridine (tpy), one 2-(phenylazo)pyridine (azpy) and a Br atom in trans-axial position at a distance of 2.547(5)A.