Publications by authors named "Kangzhuang Yuan"

Article Synopsis
  • - The study investigates early indicators and risk factors for severe dengue (SD) to improve patient triage and treatment, highlighting its critical nature as a public health issue.
  • - A systematic review analyzed 87 studies that included over 35,000 dengue fever (DF) and 8,173 SD cases, identifying 64 factors affecting prognosis and distinguishing 34 that showed significant differences between DF and SD.
  • - The findings establish practical biomarkers and clinical factors for early SD identification, aiming to enhance diagnosis and treatment, as well as to deepen understanding of SD's clinical manifestations and causes.
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Guangdong is a main dengue epidemic area in China and undergoes dengue outbreaks frequently. In 2014, Guangdong experienced a serious dengue outbreak with 45,224 confirmed cases and six deaths, which might affect the seroprevalence among the local population. There is evidence that dengue virus (DENV) infection during pregnancy may cause adverse outcomes.

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Dengue virus infection (DEN) is one of the most prevalent arbovirus diseases in the tropical and subtropical areas. Some human leukocyte antigen (HLA) alleles have been reported to be a protective or risk factor to DEN. Due to the limited sample sizes and regional limitations, the results of individual studies were various.

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