Increasing incidence of and persistent reporting of in imported malaria cases: an analysis of 9-year surveillance data in four areas of China.

Background: This study aimed at exploring the epidemiological pattern of imported malaria in China before malaria elimination in 2021, to provide evidence-based data for preventing malaria re-establishment in China.

Methods: Nine-year surveillance data on imported malaria in four provincial-level administrative divisions (PLADs) (Anhui, Chongqing, Guangxi, and Zhejiang) between 2011 and 2019 were thoroughly collected and analyzed.

Results: A quite stable trend in imported malaria cases between 2011 and 2019 was observed.

Evaluation of an Innovative Point-of-Care Rapid Diagnostic Test for the Identification of Imported Malaria Parasites in China.

Background: China was certified malaria-free by the World Health Organization on 30 June 2021. However, due to imported malaria, maintaining a malaria-free status in China is an ongoing challenge. There are critical gaps in the detection of imported malaria through the currently available tools, especially for non- malaria.

Evaluation of Malaria Standard Microscopy and Rapid Diagnostic Tests for Screening - Southern Tanzania, 2018-2019.

What Is Already Known About This Topic?: Microscopy is the gold standard for parasitological confirmation, but the accuracy of microscopic diagnosis is influenced by the skill of the technicians. An alternative is the immunologic-based malaria rapid diagnostic tests (mRDTs).

What Is Added By This Report?: Our study evaluated standard microscopy in health system (SMHS) and mRDTs for focused screening and treatment of malaria (FSAT) in Southern Tanzania.

Asymptomatic malaria infection at the China-Vietnam border: Knowledge and implications for the cross-border migrant population during the COVID-19 pandemic.

Background: Eliminating malaria along the China-Vietnam border remains one of the greatest challenges in China, especially during the coronavirus disease 2019 (COVID-19) pandemic, which has disrupted the continuity of malaria control and elimination programs. Understanding the factors associated with asymptomatic malaria infection will inform control interventions aimed at elimination of the disease among migrants from Vietnam working in China, who constitute an at-risk population.

Methods: From March 2018 to September 2019, 108 migrants from Vietnam working in Ningming County, Guangxi, were enrolled in this study.

A Case Study on the Disease Burden and Influencing Factors of Imported Malaria Patients in a County-Level Hospital - Guangxi Zhuang Autonomous Region, China, 2016-2019.

What Is Already Known On This Topic?: Imported malaria cases endanger people's health and potentially cause local re-transmission, and they may also cause economic loss on patients' families and society as a whole.

What Is Added By This Report?: This is the first report to focus on the disease burden of a case study incurred by the imported malaria. The results indicated that the median direct medical cost was 2,904.

Characterization of , , , , and in Travelers Returning from Africa with Plasmodium falciparum Infections Reported in China from 2014 to 2018.

The artemisinin-based combination therapies (ACTs) used to treat Plasmodium falciparum in Africa are threatened by the emergence of parasites in Asia that carry variants of the Kelch 13 (K13) locus with delayed clearance in response to ACTs. Single nucleotide polymorphisms (SNPs) in other molecular markers, such as and , were associated with artemisinin resistance in rodent malaria and clinical failure in African malaria patients. Here, we characterized the polymorphisms in , , , , and among African isolates reported in Shandong and Guangxi provinces in China.

Effectiveness of the innovative 1,7-malaria reactive community-based testing and response (1, 7-mRCTR) approach on malaria burden reduction in Southeastern Tanzania.

Background: In 2015, a China-UK-Tanzania tripartite pilot project was implemented in southeastern Tanzania to explore a new model for reducing malaria burden and possibly scaling-out the approach into other malaria-endemic countries. The 1,7-malaria Reactive Community-based Testing and Response (1,7-mRCTR) which is a locally-tailored approach for reporting febrile malaria cases in endemic villages was developed to stop transmission and Plasmodium life-cycle. The (1,7-mRCTR) utilizes existing health facility data and locally trained community health workers to conduct community-level testing and treatment.

Dysbiosis in Peripheral Blood Mononuclear Cell Virome Associated With Systemic Lupus Erythematosus.

Pathogen infection plays a role in the development and progression of systemic lupus erythematosus (SLE). Previous studies showed that peripheral blood mononuclear cells (PBMCs) harbor many viral communities. However, little is known about the viral components and the expression profiles of SLE-associated virome.

Overexpression of the human cytomegalovirus UL111A is correlated with favorable survival of patients with gastric cancer and changes T-cell infiltration and suppresses carcinogenesis.

Purpose: We previously found that human cytomegalovirus (HCMV) infection is associated with gastric cancer (GC) development. UL111A plays a role during HCMV productive or latent infection. However, UL111A expression profiles in GC tissues and their relationship with this disease are unknown.

Tumor-Infiltrating Immune Cells Act as a Marker for Prognosis in Colorectal Cancer.

Tumor-infiltrating immune cells (TIICs) play essential roles in cancer development and progression. However, the association of TIICs with prognosis in colorectal cancer (CRC) patients remains elusive. Infiltration of TIICs was assessed using ssGSEA and CIBERSORT tools.

K13-propeller gene polymorphisms of Plasmodium falciparum and the therapeutic effect of artesunate among migrant workers returning to Guangxi, China (2014-2017).

Background: The resistance of Plasmodium falciparum to artemisinin has been identified in Asia and some parts of Africa. The drug resistance of P. falciparum will be an obstacle to the successful elimination of malaria by 2025.

[Epidemic situation and control strategy of malaria in Guangxi Zhuang Autonomous Region from 2011 to 2018].

Objective: To analyze the epidemic situation of malaria and explore the targeted control strategy in Guangxi from 2011 to 2018.

Methods: The malaria surveillance data were collected in Guangxi Zhuang Autonomous Region from 2011 to 2018, and a descriptive method was employed to analyze the epidemiological features of the malaria cases.

Results: A total of 2 944 malaria cases were reported in Guangxi Zhuang Autonomous Region from 2011 to 2018, including a case with local infection (0.

Investigation and Evaluation of Genetic Diversity of Kelch 13 Polymorphisms Imported From Southeast Asia and Africa in Southern China.

In this study, we aimed to analyse the genetic diversity Kelch 13 (K13) propeller allele of the isolates mainly imported from Southeast Asia and Africa in southern China, including the provinces of Yunnan and Guangxi. At enrolment, we collected blood samples from patients with confirmed cases of malaria infection between January 2012 and December 2017, for analysis. Individual patient information was obtained via a malaria surveillance system.

Malaria in the Guangxi Zhuang Autonomous Region in China: A Twelve-Year Surveillance Data Study.

The incidence of an indigenous malaria, defined as malaria acquired by a local mosquito transmission, declined from 2004 to 2015 in the Guangxi Zhuang Autonomous Region. However, imported malaria, defined as malaria acquired from other endemic regions outside of China, has been increasing in the region, as in the rest of the country, particularly the disease caused by . A retrospective study was conducted to explore malaria-endemic characteristics in Guangxi during the 2004-2015 timeframe; a total of 2,726 confirmed malaria cases were reported, and the majority (90.

[Analysis of imported malaria epidemic situation and implication for prevention and control strategy in Guangxi Zhuang Autonomous Region in 2014].

Objective: To analyze the epidemic characteristics of the imported malaria cases in Guangxi Zhuang Autonomous Region in 2014, so as to assess the transmission risk and explore the prevention and control strategy.

Methods: The data of the malaria epidemic situation in the network direct report system of Guangxi in 2014 and the annual report of malaria epidemic situation in 14 cities were collected. The epidemiological information of the imported malaria cases was analyzed.

[Malaria epidemiological situation in Wuzhou City, Guangxi Zhuang Autonomous Region from 1950 to 2015].

Objective: To review and investigate the malaria control history of Wuzhou City, Guangxi Zhuang Autonomous Region from 1950 to 2015, so as to provide the evidence for future malaria control and surveillance.

Methods: The data of malaria control in Wuzhou City from 1950 to 2015 were collected and analyzed.

Results: In 1950 decade, the malaria incidence in Wuzhou City was 1 435.

[Analysis of malaria epidemiological characteristics in Hechi City, Guangxi Zhuang Autonomous Region from 2005 to 2015].

Objective: To analyze the epidemiological characteristics of malaria in Hechi City, Guangxi Zhuang Autonomous Region from 2005 to 2015, so as to provide the evidence for formulating and adjusting measures of malaria elimination.

Methods: The data of malaria cases in 11 counties of Hechi City from 2005 to 2015 were collected and analyzed by using Micro-soft Office Excel 2003 and SPSS 17.0.

[A case of neonatal congenital malaria accompanied with severe thrombocytopenia].

This article reports the process of diagnosis and treatment of one case of neonatal congenital malaria accompanied with severe thrombocytopenia.

[Analysis of epidemic situation of malaria in Longlin Various Nationalities Autonomous County in Guangxi from 1951 to 2014].

Objective: To analyze the data of epidemic situation of malaria in Longlin Various Nationalities Autonomous County, Guangxi Zhuang Autonomous Region, China from 1951 to 2014 and discuss the distribution characteristics and epidemic law, so as to provide the evidences for developing the prevention and control strategies of the disease.

Methods: The data about the epidemic situation of malaria in Longlin Various Nationalities Autonomous County were collected and analyzed statistically with Excel 2007.

Results: Totally 93 460 malaria cases were reported from 1951 to 2014 in the county.

Distribution and frequency of G119S mutation in ace-1 gene within Anopheles sinensis populations from Guangxi, China.

Background: Malaria is one of the most serious vector-borne diseases in the world. Vector control is an important measure for malaria prevention and elimination. However, this strategy is under threat as disease vectors are developing resistance to insecticides.

[Effect of malaria surveillance and control of Guangxi Zhuang Autonomous Region in 2013].

Objective: To evaluate the effect of malaria surveillance and control of Guangxi Zhuang Autonomous Region in 2013, and explore the suited surveillance and management of imported malaria cases, so as to provide the evidence for formulating the scientific control measures of imported malaria.

Methods: The endemic data and control measures of malaria in Guangxi in 2013 were collected and analyzed statistically.

Results: A total of 1 251 malaria cases were found in Guangxi in 2013, with 88.

Malaria imported from Ghana by returning gold miners, China, 2013.

During May-August 2013, a malaria outbreak comprising 874 persons in Shanglin County, China, was detected among 4,052 persons returning from overseas. Ghana was the predominant destination country, and 92.3% of malarial infections occurred in gold miners.