Publications by authors named "Kangli Guo"

The combination of nanoparticles and tumor-targeting bacteria for cancer immunotherapy can overcome the shortcomings of poor nanoparticle accumulation, limited penetration, and restricted distribution. However, it remains a great challenge for the hybrid system to improve therapeutic efficacy through the simultaneous and controllable regulation of immune cells and tumor cells. Herein, a hybrid therapeutic platform is rationally designed to achieve immune cascade-augmented cancer immunotherapy.

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Carbon monoxide (CO) gas therapy demonstrates great potential to induce cancer cell apoptosis and antitumor immune responses, which exhibits tremendous potential in cancer treatment. However, the therapeutic efficacy of CO therapy is inhibited by the immunosuppressive tumor microenvironment (TME). Herein, a facile strategy is proposed to construct hollow-structured rough nanoplatforms to boost antitumor immunity and simultaneously reverse immunosuppression by exploring intrinsic immunomodulatory properties and morphological optimization of nanomaterials.

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Safe and efficient antibacterial materials are urgently needed to combat drug-resistant bacteria and biofilm-associated infections. The rational design of nanoparticles for flexible elimination of biofilms remains challenging. Herein, we propose the fabrication of Janus-structured nanoparticles targeting extracellular polymeric substance to achieve dispersion or near-infrared (NIR) light-activated photothermal elimination of drug-resistant biofilms, respectively.

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Natural melanin nanoparticles (MNPs) have demonstrated a potential for eliciting antitumor immune responses through inducing immunogenic cell death (ICD); however, the tumor microenvironment (TME) has been shown to inhibit T cell-mediated antitumor immunity. To address this challenge, we designed TME-responsive biodegradable melanin/MnO nanohybrids via a biomineralization process. Under near-infrared (NIR) light irradiation, the photothermal property of melanin/MnO nanohybrids triggers ICD and release of tumor-associated antigens (TAAs), while Mn and TAAs induce dendritic cell (DC) maturation to provoke immune responses.

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Article Synopsis
  • Research showed that asparagine, when added to a growth medium at 10 mM concentration, provided significant protection and recovery for a strain of bacteria (SC2) under high salinity conditions (1.50% NaCl).
  • The addition of asparagine led to increased levels of related metabolites and changes in the bacteria's protein expression, particularly those involved in cell division and metabolic processes.
  • Ultimately, asparagine helped these bacteria manage salt stress by acting as a carbon source and influencing their overall metabolic activity, which is crucial given their role in reducing methane emissions in wetland ecosystems.
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Background: Endoscopic ultrasonography (EUS) is recommended as the best tool for evaluating gastric subepithelial lesions (SELs); nonetheless, it has difficulty distinguishing gastrointestinal stromal tumors (GISTs) from leiomyomas and schwannomas. GISTs have malignant potential, whereas leiomyomas and schwannomas are considered benign.

Purpose: This study aimed to establish a combined radiomic model based on EUS images for distinguishing GISTs from leiomyomas and schwannomas in the stomach.

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  • Mount Xianbei is a major seamount in the South China Sea, which may influence the biodiversity of harmful algal bloom (HAB) phytoplankton species in nearby coastal waters.
  • A 2021 study identified 19 HAB species, including 6 previously unreported ones, showcasing a significant diversity in the seamount region and a close connection between seamounts and coastal areas.
  • This research offers the first comprehensive analysis of phytoplankton spatial diversity and vertical distribution in Xianbei, providing new insights into the factors contributing to HAB occurrences in northern SCS.
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Injectable functional biomaterials have made significant progress in cardiac regenerative. In addition, how to adjust the abominable infarction microenvironment and introduce therapeutic stem cells to improve the healing effect has become a hotspot. Herein, injectable stem cell vector is prepared by combining natural alginate hydrogel and Au@Pt nanoparticles (Au@Pt/Alg hydrogel) to encapsulate brown adipose stem cells (BASCs).

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Cognatishimia activa, previously known as , has been frequently isolated from marine environments. Here, we present the complete genome sequence of . strain SOCE 004, assembled from the phycosphere of a long-term laboratory-maintained culture of the diatom Skeletonema tropicum.

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A high NH load is known to inhibit bacterial methane oxidation. This is due to a competition between CH and NH for the active site of particulate methane monooxygenase (pMMO), which converts CH to CHOH. Here, we combined global proteomics with amino acid profiling and nitrogen oxides measurements to elucidate the cellular acclimatization response of sp.

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Transparent exopolymer particles (TEP) are sticky polymeric substances that are commonly found in the periphery of microbial cells or colonies. They can naturally flocculate smaller suspended particles into larger aggregates and thus play a crucial role in the biological pump and the global carbon cycle. Phytoplankton are the major contributors to marine TEP production, whereas the way TEP production interacts with abiotic factors at the species level is generally unknown but critical for estimating carbon fluxes.

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Background: Biliary dilatation is a rare disease involving intrahepatic and extrahepatic biliary tract abnormalities. With the development of imaging technology, an increasing number of special cases have been diagnosed, which poses a challenge to the traditional classification method.

Case Presentation: A 50-year-old woman was admitted to the hospital due to right upper quadrant pain for more than 10 days.

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() is one of the dominant algae during harmful algal blooms (HABs) in coastal regions of Southern China. exhibits complex heteromorphic life cycles that could switch between solitary cells and colonies. The ecological success of has been attributed to its colony formation, although underlying mechanisms remain unknown.

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The protumoral and immunosuppressive tumor microenvironments greatly limit the antitumor immune responses of nanoparticles for cancer immunotherapy. Here, the intrinsic immunomodulatory effects of orchestrated nanoparticles and their ability to simultaneously trigger tumor antigen release, thereby reversing immunosuppression and achieving potent antitumor immunity and augmented cancer therapy, are explored. By optimizing both the composition and morphology, a facile strategy is proposed to construct yolk-shell nanohybrids (Fe O @C/MnO -PGEA, FCMP).

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In this review, we summarize the rational design and versatile application of organic/inorganic hybrid gene carriers as multifunctional delivery systems. Organic/inorganic nanohybrids with both organic and inorganic components in one nanoparticle have attracted intense attention because of their favorable properties. Particularly, nanohybrids comprising cationic polymers and inorganic nanoparticles are considered to be promising candidates as multifunctional gene delivery systems.

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Composted sewage sludge (CS) is considered a rich source of soil nutrients and significantly affects the physical, chemical, and biological characteristics of soil, but its effect on specific enzyme activity in soil is disregarded. The present experiment examined the absolute and specific enzyme activity of the enzymes involved in carbon, nitrogen, and phosphorus cycles, the diversity of soil microbial functions, and soil community composition in a Fluventic Ustochrept under a maize-wheat rotation system in North China during 2012-2015. Application of CS led to increase in MBC and in its ratio to both total organic carbon (TOC) and microbial biomass nitrogen (MBN).

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Article Synopsis
  • The experiment utilized non-hazardous sewage sludge on sandy fluvo-aquic soil during 2013-2015 to study its effects on soil carbon pools within a wheat-maize rotation system.
  • Results showed that the application of sewage sludge significantly enhanced various forms of carbon in the soil, including total organic carbon, microbial biomass carbon, labile organic carbon, and dissolved organic carbon, particularly at the highest application rate of 45 t·hm.
  • The research highlighted that while soil carbon content increased, certain ratios of carbon utilization decreased, indicating improved stable carbon content, and ultimately, the carbon pool management index considerably increased, suggesting better soil nutrient dynamics.
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