Publications by authors named "Kangli Fan"

Background And Purpose: Differentiating Parkinson's Disease (PD) from Atypical Parkinsonism Syndrome (APS), including Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP), is challenging, and there is no gold standard. Integrating quantitative susceptibility mapping (QSM) and morphometry can help differentiate PD from APS and improve the internal diagnosis of APS.

Materials And Methods: In this retrospective study, we enrolled 55 patients with PD, 17 with MSA-parkinsonian type (MSA-P), 15 with MSA-cerebellar type (MSA-C), and 14 with PSP.

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Parkinson's disease (PD), a neurodegenerative disorder characterized by impaired motor function, is typically treated with medications and surgery. However, recent studies have validated physical exercise as an effective adjunct therapy, significantly improving both motor and non-motor symptoms in PD patients. Irisin, a myokine, has garnered increasing attention for its beneficial effects on the nervous system.

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Article Synopsis
  • Positron emission tomography/computed tomography (PET/CT) is a key imaging technique used to diagnose and differentiate Parkinson's disease (PD) from similar disorders in this study involving 220 patients with PD-like symptoms.
  • The study assessed the effectiveness of two tracers, C-2β-Carbomethoxy-3β-(4-fluorophenyl) tropane (C-CFT) and F-fluorodeoxyglucose (F-FDG), in distinguishing between PD, multiple system atrophy parkinsonian type (MSA-P), progressive supranuclear palsy (PSP), and vascular parkinsonism (VP).
  • Results indicated that PSP patients had the lowest C-C
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Parkinson's disease (PD) ranks as the second most prevalent neurodegenerative disorder globally, marked by a complex pathogenesis. Lipocalin-2 (LCN2) emerges as a crucial factor during the progression of PD. Belonging to the lipocalin family, LCN2 is integral to several biological functions, including glial cell activation, iron homeostasis regulation, immune response, inflammatory reactions, and oxidative stress mitigation.

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Article Synopsis
  • The text includes a correction to an article published with the DOI 10.3389/fneur.2023.1195577.
  • This correction aims to address errors or inaccuracies that may have been present in the original publication.
  • It is important for the integrity of academic research that corrections are made to ensure the information is accurate and reliable.
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Objective: This study aims to explore the difference between C-methyl-N-2β-carbomethoxy-3β-(4-fluorophenyl)-tropanel (C-CFT) positron emission tomography (PET) imaging in the early-onset Parkinson's disease (EOPD) and late-onset Parkinson's disease (LOPD), and to analyze the correlation between C-CFT PET imaging and disease duration, Hoehn & Yahr (H&Y) stage, motor symptoms, and non-motor symptoms in patients with idiopathic Parkinson's disease (PD), so as to explore its application value in assessing the severity of Parkinson's disease.

Materials And Methods: A total of 113 patients with idiopathic PD were included in this study. The patients were divided into EOPD and LOPD groups according to the age of 60 years, of which 58 were early-onset and 55 were late-onset.

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Objective: Evaluation of the correlation between F-fluorodeoxyglucose-positron emission tomography (F-FDG PET) and cognitive function in first-diagnosed and untreated Parkinson's disease (PD) patients.

Materials And Method: This cross-sectional study included 84 first diagnosed and untreated PD patients. The individuals were diagnosed by movement disorder experts based on the 2015 MDS Parkinson's disease diagnostic criteria.

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