Size Control and Biological Properties of PAMAM-Cored Multiarm Block Copolymers.

Size is one of the crucial factors influencing the biological properties of nanomedicines. However, the size control of nanomaterials is still very challenging, and the size effect on their biological properties is worth studying. Herein, we present the synthesis and size control of a series of multiarm block copolymers with the third-generation PAMAM (G3 PAMAM) as the core.

Targeting and microenvironment-improving of phenylboronic acid-decorated soy protein nanoparticles with different sizes to tumor.

It is essential for nanoparticles to delivery drugs accurately and penetrate deeply to tumor. However, complicated tumor microenvironment such as elevated tumor interstitial fluid pressure (IFP) and solid stress reduces the transport efficiency of nanomedicines in tumor. We herein report a drug delivery system of phenylboronic acid-decorated soy protein nanoparticles with the size of 30 nm, 50 nm and 150 nm.

Cisplatin-Rich Polyoxazoline-Poly(aspartic acid) Supramolecular Nanoparticles.

Cisplatin-rich supramolecular nanoparticles are constructed through the supramolecular inclusion interaction between the admantyl (Ad)-terminated poly(aspartic acid) (Ad-P(Asp)) and the β-cyclodextrin (β-CD)-terminated poly(2-methyl-2-oxazoline). In the formation of the nanoparticles, the β-CD/admantane inclusion complex integrates poly(2-methyl-2-oxazoline) and poly(aspartic acid) chains to form pseudoblock copolymers, followed by the coordination between carboxyl groups in P(Asp) block and cisplatin. This coordination interaction drives the formation of nanoparticle and enables cisplatin incorporated into the nanoparticles.

Carbamoylmannose enhances the tumor targeting ability of supramolecular nanoparticles formed through host-guest complexation of a pair of homopolymers.

Conjugation of sugars to antitumor drugs can facilitate drug binding to tumor cells and the saccharide motifs of bleomycins (BLMs) play a crucial role in tumor-seeking. Here, we synthesized BLM monosaccharide, carbamoylmannose, and subsequently prepared carbamoylmannose decorated platinum-incorporating supramolecular nanoparticles formed through the host-guest complexation of poly(N-vinylpyrrolidone) and poly(aspartic acid). The targeting effects of carbamoylmannose decorated supramolecular nanoparticles in various cancer cells and tumor-bearing mice were investigated.

Delivery of doxorubicin in vitro and in vivo using bio-reductive cellulose nanogels.

A methacrylation strategy was used to functionalize carboxymethyl cellulose and prepare redox-sensitive cellulose nanogels which contained disulfide bonds. Dynamic light scattering, zeta potential and electron microscopy were utilized to characterize these nanogels. It was found that these nanogels had a spherical morphology with a diameter of about 192 nm, and negative surface potential.