Publications by authors named "Kanghui Xiang"
Immunotherapy is becoming increasingly important, but the overall response rate is relatively low in the treatment of gastric cancer (GC). The application of tumor mutational burden (TMB) in predicting immunotherapy efficacy in GC patients is limited and controversial, emphasizing the importance of optimizing TMB-based patient selection. By combining TMB and major histocompatibility complex (MHC) related hub genes, we established a novel TM-Score.
View Article and Find Full Text PDFA 37-year-old female patient presented with shortness of breath, cough, and chest pain complaints from the 12th week of her first pregnancy. At the 28th week, labor induction had to be performed because of severe dyspnea and hyoxemia. Thereafter, a diffused pulmonary embolism was detected by echocardiography and CT angiography, without histological diagnosis.
View Article and Find Full Text PDFTargeting the immune checkpoint B7-H3 for next-generation cancer immunotherapy.
Cancer Immunol Immunother
July 2022
Article Synopsis
- Immune checkpoint inhibitors (ICIs) targeting PD-1 and PD-L1 are popular treatments for advanced cancers, but their effectiveness is limited, leading to exploration of new targets like B7-H3.
- Recent clinical trials have shown promise for B7-H3 as a therapeutic target, highlighting its potential in improving cancer treatment outcomes.
- The review discusses the challenges and opportunities of B7-H3 therapies while emphasizing the need for further research to understand its biology and maximize its clinical benefits.
Background: Among colon cancer patients, liver metastasis is a commonly deadly phenomenon, but there are few prognostic models for these patients.
Methods: The clinicopathologic data of colon cancer with liver metastasis (CCLM) patients were downloaded from the Surveillance, Epidemiology and End Results (SEER) database. All patients were randomly divided into training and internal validation sets based on the ratio of 7:3.