Publications by authors named "Kangan Tan"
The differences between Chinese herbal medicine (CHM)- and Western medicine (WM)-induced liver injury have rarely been reported. Our aim was to investigate the clinical features of patients with drug-induced liver injury (DILI) caused by CHM or WM. The medical records of 726 DILI patients were retrospectively collected at Peking University First Hospital from January 1995 through August 2019.
View Article and Find Full Text PDFBackground: Tumor-derived organoid, namely tumoroid, can realistically retain the clinicopathologic features of original tumors even after long-term expansion. Here we develop this production methodology derived from hepatocellular carcinoma primary samples and generate a platform to evaluate the tumoricidal efficacy of autologous adoptive cell transfer including tumor infiltrating lymphocytes and peripheral blood lymphocytes.
Methods: Haematoxylin and eosin together with immunohistochemistry staining were employed to ascertain the morphologic and histological features of tumoroids and original tumors.
Since December 2019, coronavirus disease (COVID-19) has rapidly swept the world. So far, more than 30 million people have been infected and nearly one million have died. Although the world is still in the stage of COVID-19 pandemic, the treatment of new cases and critically ill patients is the focus of the current work.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted to investigate single-nucleotide polymorphisms (SNPs) that could indicate a person's susceptibility to herb-induced liver injury (PM-DILI) in China, where this is a significant health issue.
- Researchers analyzed genetic data from 382 participants, including patients with PM-DILI, other types of drug-induced liver injury, and healthy controls, to identify SNPs associated with PM-DILI.
- Results revealed three SNPs, particularly rs1055348, had significantly higher frequencies in PM-DILI patients and may serve as a specific risk factor for this condition, suggesting its potential as a biomarker for both PM-DILI and other drug-induced liver injuries.
Background & Aims: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease manifested with the aberrant activation of hepatic dendritic cells (HDCs) and the subsequent breakdown of immune homeostasis. As an important player, HDC maintains immunological balance between tolerance to self-antigens versus destruction against pathogens in liver. However, the intracellular signalling networks that program HDC remain unclear.
View Article and Find Full Text PDFA human ciliopathy with polycystic ovarian syndrome and multiple subcutaneous cysts: A rare case report.
Medicine (Baltimore)
December 2018
Rationale: Ciliopathies is a group of clinically and genetically overlapping disorders due to cilia abnormalities and multiple organ systems are involved in.
Patient Concerns: We present a young female patient who showed renal function impairment, Caroli syndrome (CS), liver cirrhosis, polycystic ovarian syndrome, and multiple subcutaneous cysts.
Diagnoses: The patient was diagnosed with ciliopathy according to the clinical manifestations and whole-genome sequencing.