Targeting CLK4 inhibits the metastasis and progression of breast cancer by inactivating TGF-β pathway.

Triple-negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer that is highly resistant to current therapeutic options. According to the public databases Oncomine and KM plotter, the CLK4 expression is correlated with poor patient survival in TNBC, especially in mesenchymal-like TNBC (MES-TNBC) that has strong metastatic potential. Therefore, we investigated the potential involvement of CLK4 in the metastasis and progression of MES-TNBC.

Standard for the Quantification of a Sterilization Effect Using an Artificial Intelligence Disinfection Robot.

Recent outbreaks and the worldwide spread of COVID-19 have challenged mankind with unprecedented difficulties. The introduction of autonomous disinfection robots appears to be indispensable as consistent sterilization is in desperate demand under limited manpower. In this study, we developed an autonomous navigation robot capable of recognizing objects and locations with a high probability of contamination and capable of providing quantified sterilization effects.

Learning Pose-Aware Models for Pose-Invariant Face Recognition in the Wild.

We propose a method designed to push the frontiers of unconstrained face recognition in the wild with an emphasis on extreme out-of-plane pose variations. Existing methods either expect a single model to learn pose invariance by training on massive amounts of data or else normalize images by aligning faces to a single frontal pose. Contrary to these, our method is designed to explicitly tackle pose variations.

Facial Landmark Detection with Tweaked Convolutional Neural Networks.

This paper concerns the problem of facial landmark detection. We provide a unique new analysis of the features produced at intermediate layers of a convolutional neural network (CNN) trained to regress facial landmark coordinates. This analysis shows that while being processed by the CNN, face images can be partitioned in an unsupervised manner into subsets containing faces in similar poses (i.