Overexpressed miRNA-155 dysregulates intestinal epithelial apical junctional complex in severe acute pancreatitis.

Aim: To investigate whether miRNA-155 (miR-155) dysregulates apical junctional complex (AJC) protein expression in experimental severe acute pancreatitis (SAP).

Methods: Twenty-four male BALB/c mice were randomly assigned to two groups: the SAP group (n = 12) receiving sequential intraperitoneal injection of 50 µg/kg caerulein and 10 mg/kg lipopolysaccharide over 6 h, and the control group (n = 12) receiving intraperitoneal injection of normal saline. Animals were sacrificed 3 h following the last injection for collection of blood samples and pancreas and distal ileal segment specimens.

Myocardial infarction following recombinant tissue plasminogen activator treatment for acute ischemic stroke: a dangerous complication.

Thrombolysis with intravenous tissue plasminogen activator (t-PA) is currently an approved therapy for patients with acute ischemic stroke. Acute myocardial infarction (AMI) immediately following t-PA treatment for stroke is a rare but serious complication. A case of acute myocardial infarction (MI) following IV t-PA infusion for acute stroke was observed.

[The relationship between HIF-1α expression and the early lung fibrosis in rats with acute paraquat poisoning].

Objective: To explore the role of hypoxia-inducible factor 1alpha (HIF-1α) in early lung fibrosis of rats with acute paraquat (PQ) poisoning.

Methods: Forty eight healthy SD rats were randomly divided into control group (6 rats) and paraquat poisoning group (42 rats). Control group was exposed to 1 ml normal solution by gastric gavage.

Effects of dynamic ventilatory factors on ventilator-induced lung injury in acute respiratory distress syndrome dogs.

Background: Mechanical ventilation is a double-edged sword to acute respiratory distress syndrome (ARDS) including lung injury, and systemic inflammatory response high tidal volumes are thought to increase mortality. The objective of this study is to evaluate the effects of dynamic ventilatory factors on ventilator induced lung injury in a dog model of ARDS induced by hydrochloric acid instillation under volume controlled ventilation and to investigate the relationship between the dynamic factors and ventilator-induced lung injuries (VILI) and to explore its potential mechanisms.

Methods: Thirty-six healthy dogs were randomly divided into a control group and an experimental group.

[The study on pro-adrenomedullin as a new biomarker in sepsis prognosis and risk stratification].

Objective: To assess the clinical value of pro-adrenomedullin (pro-ADM) in the prognosis and risk stratification in sepsis.

Methods: Fifty-one critically ill patients admitted to the intensive care unit (ICU) were prospectively stratified into four groups according to internationally recognized criteria: systemic inflammatory response syndrome (SIRS, 25 cases), sepsis (12 cases), severe sepsis (9 cases) and septic shock (5 cases). The levels of plasma pro-ADM was determined in every patient using a new sandwich immunoassay, and compared with procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6), and the acute physiology and chronic health evaluation II (APACHE II) score.

[Evaluation of mechanical ventilation for patients with acute respiratory distress syndrome as a result of interstitial pneumonia after renal transplantation].

Objective: To evaluate the clinical value of mechanical ventilation for patients with acute respiratory distress syndrome(ARDS) as a result of interstitial pneumonia after renal transplantation in the intensive care unit (ICU).

Methods: All the clinical data (totally 16 cases) were collected, including the improvement of hypoxemia before and after mechanical ventilation.

Results: Different levels of positive end-expiratory pressure (PEEP) 4-15 cm H2O (1 cm H2O=0.