Critical Role of p38 in Spinal Cord Injury by Regulating Inflammation and Apoptosis in a Rat Model.

Study Design: To evaluate the effect of p38 pathway on spinal cord injury (SCI), a rat model of SCI was performed.

Objective: We determined the effect of p38 on SCI and SCI related inflammation, apoptosis, and autophagy.

Summary Of Background Data: SCI is a severe clinical problem worldwide.

[Release kinetics of methotrexate loaded calcium phosphate cement and histological evaluation of the osteogenesis in rabbits].

Objective: To observe the release kinetics of methotrexate-loaded calcium phosphate cement (MTX-CPC) implanted in vivo and histologically investigate its resorption and osteogenesis.

Methods: MTX-CPC consisting of 1% methotrexate (MTX) (weight/weight) was pre-set and implanted into femoral muscles of 24 New Zealand rabbits. The in vivo MTX release kinetics was determined on the 1st, 2nd, 5th, 10th, 15th, 20th, 25th, and 30th post-implantation day.