Publications by authors named "Kang-Xin Tao"
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons and aggregation of α-synuclein (α-syn). Ferroptosis, a form of cell death induced by iron accumulation and lipid peroxidation, is involved in the pathogenesis of PD. It is unknown whether melatonin receptor 1 (MT1) modulates α-syn and ferroptosis in PD.
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- Parkinson's disease (PD) is the second most common neurodegenerative disorder, marked by the buildup of α-synuclein (α-syn) and neuroinflammation due to microglial activation.
- Microglia play a crucial role in PD pathology by undergoing changes that affect their ability to degrade α-syn and manage inflammation, with involvement from genes like LRRK2, GBA, and DJ-1.
- The review highlights the need for further research into how α-syn interacts with microglia, which could lead to new treatment strategies for PD by enhancing microglial autophagy and phagocytosis.