HIF-1α inhibition promotes the efficacy of immune checkpoint blockade in the treatment of non-small cell lung cancer.

The response to immune checkpoint inhibitors (ICIs) monotherapy remains unsatisfactory in patients with NSCLC. Thus, combining ICIs with other potential modalities is of great significance to enhance the response of single drug alone. Here, we identified that HIF-1α inhibition was capable of promoting anti-tumor immunity in NSCLC.

Predictive value of a reduction in the level of high-density lipoprotein-cholesterol in patients with non-small-cell lung cancer undergoing radical resection and adjuvant chemotherapy: a retrospective observational study.

Background: Cancer patients often exhibit chemotherapy-associated changes in serum lipid profiles, however, their prognostic value before and after adjuvant chemotherapy on survival among non-small-cell lung cancer (NSCLC) patients is unknown.

Methods: NSCLC patients undergoing radical resection and subsequent adjuvant chemotherapy from 2013 to 2017 at Sun Yat-sen University Cancer Center were retrospectively reviewed. Fasted serum lipid levels were measured before and after chemotherapy.

Gemcitabine and APG-1252, a novel small molecule inhibitor of BCL-2/BCL-XL, display a synergistic antitumor effect in nasopharyngeal carcinoma through the JAK-2/STAT3/MCL-1 signaling pathway.

Advanced nasopharyngeal carcinoma (NPC) has a poor prognosis, with an unfavorable response to palliative chemotherapy. Unfortunately, there are few effective therapeutic regimens. Therefore, we require novel treatment strategies with enhanced efficacy.

[Removing nitrogen from low-C/N-piggery-wastewater using shortcut nitrification/denitrification-ANAMMOX].

Aiming at the problem of deficiency of organic carbon source in piggery wastewater treatment by traditional method, shortcut nitrification/denitrification-ANAMMOX was used to remove nitrogen in piggery wastewater with low C/N in SBBR reactors. The results showed that shortcut nitrification/denitrification provided good influent conditions for ANAMMOX. High nitrogen removal efficiency of piggery wastewater by ANAMMOX was achieved and the average removal percentage of ammonium, nitrite and total nitrogen reached 91.

[Nitritation-denitrification process as a pretreatment of ANAMMOX to remove nitrogen from piggery wastewater].

Piggery wastewater with low C/N was treated by using nitritation-denitrification process to attain a suitable influent for ANAMMOX at ambient temperature (13-20 degrees C) without pH control. By using this process, part of total nitrogen and COD were removed, the ratio of ammonium and nitrite reached around 1:1 and the pH was about 7.8, which were favorable for ANAMMOX.