Publications by authors named "Kang-Jin Li"
Article Synopsis
- CircSMARCC1, a type of circular RNA, is found to be significantly increased in prostate cancer (PCa) cells and tissues, playing a critical role in tumor growth and spread.* -
- The study demonstrated that circSMARCC1 enhances the expression of CCL20 by inhibiting miR-1322, activating the PI3K-Akt signaling pathway, and facilitating M2 polarization of tumor-associated macrophages (TAMs), which contributes to PCa progression.* -
- High levels of circSMARCC1 correlate with increased infiltration of specific TAMs in the tumor microenvironment, suggesting it promotes tumor progression through interactions between cancer cells and macrophages.*
Background: More and more studies have shown that circular RNAs (circRNAs) play a critical regulatory role in many cancers. However, the potential molecular mechanism of circRNAs in prostate cancer (PCa) remains largely unknown.
Methods: Differentially expressed circRNAs were identified by RNA sequencing.