Exploring the impact of dietary factors on intracranial aneurysm risk: insights from Mendelian randomization analysis.

Background: While existing research has established a link between dietary habits and the incidence of intracranial aneurysms, the application of Mendelian randomization to explore this association remains largely uncharted.

Methods: In our study, we analyzed a wide array of dietary factors using data from the IEU Open GWAS project, which included meat varieties, vegetarian foods, cereal and the frequency of alcohol intake. We included pooled intracranial aneurysm GWAS data from a comprehensive dataset of 7,495 cases.

Metabolic pathway and genetically causal links of 1,400 circulating metabolites on the risk of intracranial aneurysms and aneurysmal subarachnoid hemorrhage.

Background: The rupture of intracranial aneurysms (IAs) leads to aneurysmal subarachnoid hemorrhage (aSAH), which is associated with significant disability and mortality rates. This study aims to identify metabolic markers causally linked to the occurrence of IAs and aSAH through Mendelian randomization (MR), thereby offering novel predictive and therapeutic targets.

Methods: We conducted a genome-wide association study (GWAS) on IAs and aSAH, analyzing 1,400 metabolomic indices from the Canadian Longitudinal Study on Aging (CLSA) cohort (n = 8,299).

Identifying novel risk genes in intracranial aneurysm by integrating human proteomes and genetics.

Genome-wide association studies (GWAS) have become increasingly popular for detecting numerous loci associated with intracranial aneurysm (IA), but how these loci function remains unclear. In this study, we employed an integrative analytical pipeline to efficiently transform genetic associations and identify novel genes for IA. Using multidimensional high-throughput data, we integrated proteome-wide association studies (PWAS), transcriptome-wide association studies (TWAS), Mendelian randomization (MR) and Bayesian co-localization analyses to prioritize genes that can increase IA risk by altering their expression and protein abundances in the brain and blood.

Exact optical path difference and complete performance analysis of a spectral zooming imaging spectrometer.

The optical path difference (OPD) equations of the dual Wollaston prisms (DWP) with an adjustable air gap (AG) are derived by the wave normal tracing method, which is suitable for arbitrary incidence plane and angle. The spatial distribution of the OPD for various AG is presented. The validity of the OPD equation is verified by comparing the calculated interferograms with experimentally observed one.

Snapshot broadband polarization imaging based on Mach-Zehnder-grating interferometer.

Full polarization imaging plays an important role in remote sensing to distinguish artificial objects from the natural environment, recognizing objects in shadows and sun glint suppression. In this paper, we propose a broadband full Stokes channeled modulated polarization imaging system based on a Mach-Zehnder-grating interferometer (MZGI) with advantages such as compact size, low cost, snapshot ability, and high optical efficiency. It uses gratings to compensate for the dispersion of the carried frequency when inputting broadband light to generate interference fringes.

Transparent intersatellite optical wireless communication link with double sideband-suppressed carrier modulation and coherent homodyne detection.

In this paper, we present an intersatellite optical wireless communication (IsOWC) link with double sideband-suppressed carrier (DSB-SC) modulation and coherent homodyne detection (CD), which enables transparent transport of multiband radio frequency (RF) signals. The performance of transparent multiband IsOWC link employing DSB-SC/CD and phase modulation with CD (PM/CD) is investigated. The theoretical model considers the finite extinction ratio (ER) of a Mach-Zehnder modulator (MZM) and the saturation property of an optical booster amplifier.

Novel tetrahydrofuran derivatives from Trigonostemon howii with their potential anti-HIV-1 activities.

A novel tetrahydrofuran derivative, trigonohowine (1), together with five known tetrahydrofuran derivatives (2-6), were isolated from the stems and leaves of Trigonostemon howii. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with the data reported in literature. Among them, trigonohowine (1) represents the first example of a new type of tetrahydrofuran derivative, possessing an unprecedented carbon skeleton containing 23 carbon atoms on the carbon skeleton and the known compouds (2-6) are rare tetrahydrofuran derivatives in the plant kingdom with various carbon skeletons.

Ochroborbone, A New Cytotoxic Indole Alkaloid from Ochrosia borbonica.

A new monoterpenoid indole alkaloid, ochroborbone (1), along with five known alkaloids (2-6), were isolated from the stems and leaves of Ochrosia borbonica. Among them, ochroborbone (1) is a rare C17-nor monoterpenoid indole alkaloid, and the known compounds (2-6) were isolated from Ochrosia for the first time-These structures were established on the basis of extensive spectroscopic methods. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro.

Ochroborbone, A New Cytotoxic Indole Alkaloid from Ochrosia borbonica.

A new monoterpenoid indole alkaloid, ochroborbone (1), along with five known alkaloids (2-6), were isolated from the stems and leaves of Ochrosia borbonica. Among them, ochroborbone (1) is a rare C17-nor monoterpenoid indole alkaloid, and the known compounds (2-6) were isolated from Ochrosia for the first time. These structures were established on the basis of extensive spectroscopic methods.