Publications by authors named "Kang Xun"

This study reports the successful synthesis and comprehensive characterization of TiRhSiO and TiIrSiO, the earliest identified members of Ti-based AuAl-type materials. These compounds crystallize in the cubic space group 23 (No. 198), with refined lattice parameters of 6.

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Background: The radial artery deviation and reimplantation (RADAR) technique uses an artery-to-vein (end-to-side) configuration. We have developed a modified RADAR (M-RADAR) technique. This new technique enables a side-to-side anastomosis between the vessels, and furthermore, the distal cephalic vein is ligated.

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Patients with relapsed/refractory primary central nervous system lymphoma (R/R PCNSL) usually have a poor prognosis and limited treatment options. We respectively reviewed 38 patients with R/R PCNSL treated with zanubrutinib-based regimens in our center. The overall response rate, complete response rate and disease control rate were 76.

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Background: Leptomeningeal metastasis of gastric adenocarcinoma (LM-GC) is a rare and severe complication with a poor prognosis, its prognosis is significantly poorer than liver, lung, and peritoneal metastases. Studies on LM-GC have been limited to clinical case reports. Despite advances in systemic therapies, there is a lack of standardized treatment protocols for LM-GC due to its rarity and the challenges it presents.

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Introduction: Aspirin and indobufen are commonly used therapeutic drugs for the prevention of vascular restenosis (VR) after percutaneous transluminal angioplasty surgery. They both exhibited antiplatelet effects but molecular mechanisms underlying metabolic changes induced by them remain unclear.

Methods: In this study, we collected plasma samples from patients on aspirin medication ( = 5), patients on indobufen medication, patients with no medication after PTA, and healthy controls (CKs) ( = 5).

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  • - Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat to global health, with similar cases reported in Hainan.
  • - Researchers isolated a bacteriophage named vB_SauP_L1 from local sources that can effectively kill 18 out of 35 MRSA strains, showing good growth and environmental resilience.
  • - Genomic analysis of vB_SauP_L1 revealed a 17,114 bp linear double-stranded DNA with no virulent or antibiotic resistance genes, suggesting it could be a promising option for preventing and treating MRSA infections.
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The main vectors of Zika virus (ZIKV) and dengue virus (DENV) are Aedes aegypti and Ae. albopictus, with Ae. aegypti being more competent.

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Introduction: RESLES (Reversible splenial lesion syndrome) can be observed secondary to various diseases, and intramyelinic edema may play a crucial role in the pathogenesis of SCC (Splenium of the corpus callosum). Some studies have suggested that hypoxic-ischaemic encephalopathy may constitute a risk factor for SCC lesions. However, the potential impact of high-altitude environments on SCC, especially during chronic exposure, remain obscure.

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  • Hyperglycaemia leads to increased reactive oxygen species (ROS) and activates the TGF-β1/Smad pathway, contributing to diabetic nephropathy, with Indoxyl sulphate (IS) causing oxidative stress and inflammation in podocytes.
  • The study involved culturing rat podocytes and manipulating TGF-β1 levels—using siRNA silencing, overexpression, and a ROS inhibitor—to examine impacts on various protein expressions linked to kidney function.
  • Results showed that manipulating TGF-β1 and ROS levels significantly affected the expression of key proteins, indicating IS may decrease protective factors in podocytes, further implicating it in the progression of diabetic nephropathy.
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Primary central nervous system lymphoma (PCNSL) is a rare and aggressive lymphoma of the brain with poor prognosis. The scarcity of cell lines established using PCNSL makes it difficult to conduct preclinical studies on new drugs. We aimed to explore the effect of selinexor combined with zanubrutinib in PCNSL using established PCNSL cells and an orthotopic PCNSL model.

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  • Leptomeningeal metastasis (LM) is a serious complication of lung cancer, and this study examined how effective intrathecal therapy (IT) combined with other treatments is for patients suffering from it.
  • A review of 37 patient records revealed a median overall survival of 16 months, with combination therapy using tyrosine kinase inhibitors (TKIs) resulting in significantly better survival rates compared to other treatments.
  • The findings suggest that IT combined with TKIs may offer a promising treatment option for those with leptomeningeal metastasis due to lung adenocarcinoma, enhancing patient outcomes significantly.
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  • This study successfully synthesized a double perovskite oxide called CdFeReO using high-temperature and high-pressure methods, confirming its crystal structure with about 68% ordering of Fe and Re ions.
  • The Curie temperature of CdFeReO was measured at 460 K, which is above room temperature, and it exhibited a notable low-field magnetoresistance of -23% at 5 K, the highest in its family group.
  • First-principles calculations indicate that CdFeReO has a half-metallic ferrimagnetic nature, suggesting its potential applications in spintronics and materials science, while also prompting further research into its magnetoresistance behavior compared to related compounds.
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Plant-based diets have been suggested to help prevent various chronic diseases, including cancer. However, there are few reports on central nervous system tumors, and data on dose-response relationships are lacking. This individual-matched case-control study included 506 cases and 506 controls.

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  • * Research on B. pseudomallei strains with and without the tssJ-3 gene revealed that the lack of this gene significantly inhibited bacterial growth, biofilm formation, motility, and ability to invade host cells.
  • * The study found that tssJ-3 plays a crucial regulatory role in gene expression related to biofilm and flagellum development, suggesting that targeting this gene could lead to new treatments for infections caused by B. pseudomallei. *
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  • The chem16S package integrates taxonomic data from 16S rRNA gene sequences with amino acid profiles of prokaryotic reference proteomes, allowing users to build community reference proteomes.
  • It supports classifications from the RDP Classifier and data from the phyloseq package, enabling the calculation and visualization of various chemical metrics.
  • The package is developed on GitHub and version 1.0.0 is available for free on CRAN.
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Identifying modifiable factors in primary prevention strategies is a typical goal of glioma epidemiology. Among many glioma risk factors, diet was always considered as one. Most of the relevant studies thus far were concentrated on the West.

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Objective: This study was aimed at analyzing the efficacy and safety of an injectable form of chlorogenic acid (CGA) in patients with recurrent high-grade glioma after standard of care treatments, through a first-in-human, open-label, dose-escalation phase I trial.

Methods: A total of 26 eligible patients were enrolled, received intramuscular CGA injections at 5 dose levels, and were followed up for 5 years. CGA was well tolerated, and the maximum tolerated dose was 5.

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Background: In China, Community Health Centers (CHCs) provide primary healthcare (PHC); however, few studies have examined the quality of PHC services experienced by migrant patients. We examined the potential association between the quality of migrant patients' PHC experiences and the achievement of Patient-Centered Medical Home by CHCs in China.

Methods: Between August 2019 and September 2021, 482 migrant patients were recruited from ten CHCs in China's Greater Bay Area.

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  • The study focuses on mosquito-borne viruses, highlighting the importance of virome surveillance to understand and control pathogenic viruses affecting humans and animals.
  • Researchers analyzed high-depth RNA viromes from 15 species of mosquitoes in Hainan Island over three years, discovering 57 known and 39 novel viruses that demonstrate species-specific virome stability.
  • Findings suggest that virome composition is influenced by mosquito species, their food sources, and geographic conditions, indicating ecological interactions play a key role in how these viruses are distributed in different regions.
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Background: As one of the essential nutrients for the human body, minerals participate in various physiological activities of the body and are closely related to many cancers. However, the population study on glioma is not sufficient.

Objective: The purpose of this study was to evaluate the relationship between five dietary minerals and glioma.

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  • Dietary antioxidants like vitamins A, C, and E are known for their protective effects against gliomas, while the role of B vitamins in this context has been less explored.
  • A case-control study in China involved 506 glioma cases and 506 matched controls, assessing dietary intake of five B vitamins using a comprehensive food frequency questionnaire.
  • The findings indicated that higher intake of thiamine, riboflavin, nicotinic acid, and folate was linked to a reduced risk of glioma, although results for biotin varied across different glioma types and grades.
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  • * A study found that higher expression of Plant homeodomain finger protein 6 (PHF6) in UCEC tissues correlates with poorer patient survival, while mutations in PHF6 can lead to better outcomes.
  • * Reducing PHF6 levels in cancer cells inhibited their growth and enhanced immune response, suggesting that PHF6 could serve as a valuable biomarker and potential therapeutic target for treating UCEC.
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  • - Olfactory neuroblastoma is a rare and aggressive tumor in the upper nasal cavity, with very few effective treatment options available, especially for cases that have spread to the leptomeninges.
  • - A case study focused on a 59-year-old woman showed promising results using a combination of intravenous chemotherapy and intrathecal methotrexate delivered via an Ommaya reservoir to treat her olfactory neuroblastoma and leptomeningeal carcinomatosis.
  • - The treatment led to the remarkable disappearance of tumor cells in her cerebrospinal fluid and relief of her symptoms, suggesting that this method could be a new potential therapy for patients with similar meningeal metastases.
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Under high-pressure and high-temperature conditions, doped BiReO and BiOsO with Fe up to 29 atomic % were synthesized. The crystal structures and chemical compositions of BiOsFeO and BiReFeO were determined by synchrotron powder X-ray diffraction and electron probe microanalysis. Both crystal structures were explained by a KSbO-type model with the space group 3̅.

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  • Glioma is a deadly brain cancer characterized by high recurrence, with glioma stem cells (SCs) playing a key role in tumor development and progression.
  • The study found that heat shock protein 90 (HSP90) is upregulated in glioma SCs and enhances their self-renewal and metabolic activity, including glucose utilization and ATP production.
  • Using a glycolysis inhibitor (2-DG) decreased HSP90 levels and reduced the stemness of glioma cells, suggesting that targeting HSP90 could be a viable approach for developing new treatments for glioma.
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