Publications by authors named "Kang Liao"

Background: The type VI secretion system (T6SS) has been recognized as a novel virulence factor in Klebsiella pneumoniae. This study investigated the occurrence of T6SS genes in carbapenem-resistant Klebsiella pneumoniae (CRKP) strains during intestinal colonization and evaluated their effect on the development of bloodstream infections.

Methods: The study encompassed 2,385 patients admitted to the intensive care unit (ICU) and subjected to routine screening for intestinal colonization with CRKP.

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Background: Though droplet digital PCR (ddPCR) has emerged as a promising tool for early pathogen detection in bloodstream infections (BSIs), more studies are needed to support its clinical application widely due to different ddPCR platforms with discrepant diagnostic performance. Additionally, there is still a lack of clinical data to reveal the association between pathogen loads detected by ddPCR and corresponding BSIs.

Methods: In this prospective study, 173 patients with suspected BSIs were enrolled.

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Atomically dispersed transition metal (ADTM) catalysts are widely implemented in energy conversion reactions, while the similar properties of TMs make it difficult to continuously improve the activity of ADTMs via tuning the composition of metals. Introducing nonmetal sites into ADTMs may help to effectively modulate the electronic structure of metals and significantly improve the activity. However, it is difficult to achieve the co-existence of ADTMs with nonmetal atoms and clarify their synergistic effect on the catalytic mechanism.

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The volatile compounds in the fruits of 24 apricot cultivars were quantitatively and qualitatively determined via headspace solid-phase microextraction and gas chromatography-mass spectrometry (HS-SPME-GC-MS). A total of 429 volatile compounds were detected in these fruits, and the greatest number of detected terpenoids was 77. Significant differences were found among the cultivars in terms of the total volatile compound content of the fruits, with variation from 112.

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Background: Carbapenem-resistant (CRE) is rapidly becoming a major threat to hospitalized children worldwide. The purpose of this study was to summarize etiological characteristics and identify risk factors relevant to CRE bloodstream infection (BSI) and short-term mortality among pediatric patients in China.

Methods: In this study, we included 370 inpatients ≤17 years old with BSI caused by in China from January 2013 to December 2022.

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Background: , an opportunistic pathogen that can cause infections in multiple parts of the human body, has multiple drug resistance and a high mortality rate. However, there have been few reports of infective endocarditis (IE) caused by , which means that diagnosis and treatment face challenges that cannot be ignored. Rapid and accurate identification and drug sensitivity results are needed to make timely treatment adjustments.

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Article Synopsis
  • Researchers developed a new method to create a large library of carbon-supported bi- and multi-metallic single atom (SA) and atomic cluster (AC) materials, expanding on previously existing monometallic variants.
  • The study resulted in 23 bimetallic composites and additional 17 combinations including trimetallic to septenary-metallic designs, demonstrating how varying cohesive energies can lead to selective metal clustering.
  • The bimetallic materials showed promising electrocatalytic performance, with significant durability for hydrogen evolution, and the research opens up avenues for further exploration into complex material compositions and their unique effects.
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Determining the distribution trends, transport mechanisms, and ecological risks of heavy metals (HMs) in urban river sediments is essential for the government to conduct appropriate remediation work. In this study, we collected sediment cores from the Yayao Waterway in Foshan City, China. The vertical distribution profiles of dissolved and labile Fe, Mn, Cd, Zn, Cu, Cr, Ni, Pb, As, and Co in the sediments were obtained using the thin-film diffusive gradient (DGT) and high-resolution peeper (HR-Peeper) techniques.

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  • Existing panoramic layout estimation methods face challenges such as imprecise boundary recovery due to vertical compression and the need for extensive, time-consuming data annotations.
  • The proposed DOPNet introduces an orthogonal plane disentanglement approach to improve the clarity and accuracy of room layouts, consisting of three integrated modules that enhance the quality of output representations.
  • To address the data annotation issue, an unsupervised adaptation technique is presented, utilizing optimization strategies and a 1D cost volume method to leverage geometric consistency and enrich scene information from multiple perspectives, leading to superior performance in layout estimation tasks compared to current state-of-the-art models.
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Thin-plate spline (TPS) is a principal warp that allows for representing elastic, nonlinear transformation with control point motions. With the increase of control points, the warp becomes increasingly flexible but usually encounters a bottleneck caused by undesired issues, e.g.

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Article Synopsis
  • The study explores the global threat posed by carbapenem-resistant Klebsiella pneumonia (CRKP), specifically focusing on the highly virulent ST11 clone.
  • A multicenter survey conducted in China from 2011 to 2021 reveals a significant rise in KL64 serotypes, indicating its spread and evolution over time.
  • Phylogenetic analysis suggests that ST11 CRKP originated in the Americas and has developed traits associated with high mortality and resistance, highlighting the need for ongoing surveillance and intervention.
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Introduction: Preservation fluid (PF) contaminations are common in conventional liver transplantation (CLT) and presumably originate from organ or PF exposures to the external environment in a non-strict sterile manner. Such exposures and PF contamination may be avoided in ischaemia-free liver transplantation (IFLT) because of the strict sterile surgical procedures. In this study, the authors evaluated the impact of IFLT on organ PF contamination.

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  • - A study in Guangdong Province, China, observed that 6.4% of carbapenem-resistant Pseudomonas aeruginosa clinical isolates were resistant to ceftazidime-avibactam (CZA).
  • - Whole-genome sequencing of 16 CZA-resistant strains identified the presence of class B carbapenem resistance genes and highlighted the role of the PA1874 gene in this resistance.
  • - The findings underscore the importance of monitoring CZA-resistant strains and indicate that class B resistance genes are crucial to understanding CZA resistance mechanisms.
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Purpose: Blood culture (BC) remains the gold standard for the diagnosis of bloodstream infections. Improving the quality of clinical BC samples, optimizing BC performance, and accelerating antimicrobial susceptibility test (AST) results are essential for the early detection of bloodstream infections and specific treatments.

Methods: We conducted a retrospective multicenter study using 450,845 BC specimens from clinical laboratories obtained from 19 teaching hospitals between 1 January 2021 and 31 December 2021.

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  • Researchers identified seven cases of a new multidrug-resistant fungal pathogen in Guangdong, China, marking the first report in the region.
  • Whole genome sequencing revealed two geographic clades (III and I) present in different hospitals, with isolates showing resistance to fluconazole and amphotericin B due to specific genetic mutations.
  • Despite treatment, a significant portion of patients faced recurrent infections, and some continued to show colonization for long periods, emphasizing the challenges in managing this pathogen.
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Image outpainting gains increasing attention since it can generate the complete scene from a partial view, providing a valuable solution to construct 360° panoramic images. As image outpainting suffers from the intrinsic issue of unidirectional completion flow, previous methods convert the original problem into inpainting, which allows a bidirectional flow. However, we find that inpainting has its own limitations and is inferior to outpainting in certain situations.

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Chronic pulmonary infection caused by Pseudomonas aeruginosa (P. aeruginosa) is a common lung disease with high mortality, posing severe threats to public health. Highly resistant biofilm and intrinsic resistance make P.

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Background: Candida glabrata is an important cause of invasive candidiasis. Echinocandins are the first-line treatment of invasive candidiasis caused by C. glabrata.

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Background: The emergence of ceftazidime-avibactam (CZA) resistance among carbapenem-resistant (CRKP) is of major concern due to limited therapeutic options.

Methods: In this study, 10 CRKP strains were isolated from different samples of a patient with CRKP infection receiving CZA treatment. Whole-genome sequencing (WGS) and conjugation experiments were performed to determine the transferability of the carbapenem resistance gene.

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Introduction: Flavonoids, as secondary metabolites in plants, play important roles in many biological processes and responses to environmental factors.

Methods: Apricot fruits are rich in flavonoid compounds, and in this study, we performed a combined metabolomic and transcriptomic analysis of orange flesh (JN) and white flesh (ZS) apricot fruits.

Results And Discussion: A total of 222 differentially accumulated flavonoids (DAFs) and 15855 differentially expressed genes (DEGs) involved in flavonoid biosynthesis were identified.

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Background: The overuse of antibiotics in livestock is contributing to the burden of antimicrobial resistance in humans, representing a One Health challenge. Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) has recently become a growing concern, and ST9 is the major LA-MRSA lineage in China and has emerged in clinical settings.

Methods: Antimicrobial susceptibility testing was used to evaluate the tetracycline resistance of ST9 MRSA collections, and gene cloning experiments were performed to explore the resistance mechanisms.

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Not everybody can be equipped with professional photography skills and sufficient shooting time, and there can be some tilts in the captured images occasionally. In this paper, we propose a new and practical task, named Rotation Correction, to automatically correct the tilt with high content fidelity in the condition that the rotated angle is unknown. This task can be easily integrated into image editing applications, allowing users to correct the rotated images without any manual operations.

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Antibiotic stewardship has been prioritized by governments and health care organizations in recent years as antibiotic resistance is markedly increasing. A tertiary hospital in Guangzhou, China was chosen as a study example to undertake an implementation and effectiveness evaluation of China's antibiotic stewardship to improve and promote antimicrobial stewardship nationwide. The general surgery department of the study hospital was utilized to examine surgical site infection, and samples from across the hospital were used to identify bloodstream infection.

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Background: Mycoplasma hominis is one of the main opportunistic pathogenic mycoplasmas in humans which has a major impact on patients with bloodstream infections. Because it is difficult to detect or isolate, rapid and accurate diagnosis using improved methods is essential and still challenging for patients with bloodstream infection.

Case Presentation: In this case, we reported the application of next -generation sequencing for the diagnosis of bloodstream infection caused by Mycoplasma hominis in a patient with Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

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