Effect of medical mask on voice in patients with dysphonia.

Objective: Medical masks have been shown to significantly influence speech communication in healthy people. The effect of mask-wearing on phonatory capability and daily communication exchanges in patients with voice disorders remains unclear. To evaluate the effect of the medical mask on acoustic parameters in patients with a voice disorder, we measured the voice frequency, quality, and intensity.

Overview of statistics teaching within undergraduate programmes in UK and Ireland dental schools.

Introduction The United Kingdom (UK) General Dental Council's (GDC's) learning outcomes for undergraduate dental students briefly mention critical appraisal but not statistics. Hence, wide variation in statistics teaching across the dental schools is likely but has not yet been well-documented.Methods A survey was conducted to capture the main features of each of the dental degrees in the 18 UK and Ireland dental schools in terms of statistics-related (standalone or as part of other courses/modules) teaching.

Transcriptomic Characterization of miRNAs in Larvae Responding to Infection.

is a fungal pathogen that specifically infects bee larvae, causing an outbreak of chalkbrood disease in the bee colony and a decline in the number of bee colonies. The role of miRNA regulation in honeybees in response to infection is unclear. In this study, based on small RNA-seq, we identified the differentially expressed miRNAs (DEmiRNAs) and their regulatory networks and functions in the gut of on the first day (AcT1), the second day (AcT2) and the third day (AcT3) after infection, and analyzed the immune response mechanism of through the miRNAs-mRNA regulation network of infection.

Effect of sodium zirconium cyclosilicate on hyperkalemia after parathyroidectomy in secondary hyperparathyroidism patients with maintenance hemodialysis: A randomized trial.

Background: Postoperative hyperkalemia is 1 common complication after parathyroidectomy (PTX), which requires close monitoring and prompt treatment. This study aimed to determine whether using sodium zirconium cyclosilicate (SZC) would lower the risk of hyperkalemia in patients with maintenance hemodialysis after PTX.

Methods: Sixty-two patients with secondary hyperparathyroidism (SHPT) were randomly divided into the experimental and control groups.

Exploring the mechanism of action of Lobetyolin in the treatment of allergic rhinitis based on network pharmacology and molecular docking.

Lobetyolin (LBT) is an important active ingredient in the traditional medicinal plant Codonopsis pilosula (Franch.) Nannf. However, the pharmacological targets and mechanisms of action of LBT against allergic rhinitis (AR) are not known.

Genetic risk factors for periodontitis: a genome-wide association study using UK Biobank data.

Objectives: Periodontitis is linked with many health conditions, but its genetic basis is not yet understood. This genome-wide association study (GWAS) aimed to investigate the genetic variants associated with periodontitis.

Materials And Methods: This study utilised UK Biobank participants of European descent.

Adjunctive use of hyaluronic acid in non-surgical periodontal therapy: A systematic review and meta-analysis.

Introduction And Objectives: Clinical studies have shown that adjunctive use of hyaluronic acid (HA) as part of non-surgical periodontal treatment (NSPT) has led to favourable clinical outcomes. However, no systematic review and meta-analysis has been carried out recently and technical and patient factors have not been previously explored. Therefore, the aim of this systematic review and meta-analysis is to evaluate the clinical effects of topical- HA as an adjunct to NSPT on probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BoP) in periodontitis patients.

Targeting Monounsaturated Fatty Acid Metabolism for Radiosensitization of KRAS Mutant 3D Lung Cancer Models.

Mutations in the KRAS oncogene can mediate resistance to radiation. KRAS mutation (mut) driven tumors have been reported to express cancer stem cell (CSC)-like features and may harbor metabolic liabilities through which CSC-associated radioresistance can be overcome. We established a radiation/drug screening approach that relies on the growth of 3D spheres under anchorage-independent and lipid-limiting culture conditions, which promote stemness and lipogenesis.

Equity of intensive care unit bed resource allocation in ethnic minority areas of China-an empirical analysis based on geographical and population dimensions.

Objective: The purpose of this study is to analyse the changes in the equity of intensive care unit (ICU) bed allocation in 14 cities in China's Guangxi Zhuang Autonomous Region from 2018 to 2021, to identify the problems in the process of ICU bed allocation in China's ethnic minority regions.

Design: The Gini coefficient, Theil index, health resource density index, and spatial correlation analysis were used to analyse the current status of ICU bed resource allocation and allocation equity in Guangxi, China, on two dimensions: geography, and population.

Setting: The Guangxi Zhuang Autonomous Region.

Long-Term Impact of Childhood Dental Attendance on Perceived Adult Oral Health: The British Cohort Study.

Objective: To evaluate the effect of childhood dental attendance pattern on self-rated oral health in middle adulthood among the British population.

Methods: Data from the 1970 British Cohort Study involving participants born in England, Scotland, and Wales were used. Self-rated oral health was assessed at age 46.

Thiol-terminated -halamine ligands to photothermal gold nanorods for synergistically combating antibiotic-resistant bacteria.

Bio-friendly antibacterial -halamine polymers were used to modify gold nanorods (GNR@pAMPS-Cl), which showed excellent antimicrobial activity against antibiotic-resistant bacteria and accelerated the healing of MRSA-infected wounds. This work provides a new strategy for the preparation of nanoscale antibacterial materials.

[Protection of vasodilatory function in rats with post-infarction heart failure by salvianolic acid B via modulating Piezo1 channel].

To explore the regulation of vasodilatory function in rats with post-infarction heart failure by salvianolic acid B(Sal-B) based on the mechanosensitive ion channel, namely Piezo1. A post-infarction heart failure model of rats was prepared by ligation of the left anterior descending coronary artery. After successful modeling, the rats were randomly divided into the model group, Sal-B group(0.

Highly efficient adsorption of natural organic matter from aqueous solutions by macroporous weakly basic anion exchange resin: performance, mechanism, and fixed - bed column.

In this study, humic acid was used as a model pollutant to investigate the removal effect of a macroporous weakly alkaline anion exchange resin D301 on natural organic matter (NOM) in water. 3D fluorescence spectroscopy, UV - visible spectrophotometry and Fourier transform infrared (FTIR) spectroscopy were employed to analyze changes in the physical and chemical properties of humic acid solution and natural water samples before and after resin adsorption. The results showed that using humic acid as a model pollutant to simulate NOM in water is feasible.

Supramolecular Switching-Enabled Quorum Sensing Trap for Pathogen-Specific Recognition and Eradication to Treat Enteritis.

Intestinal bacterial infections have become a significant threat to human health. However, the current typical antibiotic-based therapies not only contribute to drug resistance but also disrupt gut microbiota balance, resulting in additional adverse effects on life activities. There is an urgent need to develop new antibacterial materials that selectively eliminate pathogenic bacteria without disrupting beneficial bacterial communities or promoting drug resistance.

Mechanistic insights into the regression of atherosclerotic plaques.

Atherosclerosis is a major contributor to cardiovascular diseases and mortality globally. The progression of atherosclerotic disease results in the expansion of plaques and the development of necrotic cores. Subsequent plaque rupture can lead to thrombosis, occluding blood vessels, and end-organ ischemia with consequential ischemic injury.

Higher Prevalence of Tooth Loss in People With Abdominal Obesity but Normal Weight: Findings From the United States and Scottish Populations.

Objectives: Previous research has shown that people with obesity are at a higher risk of tooth loss; however, it is unclear whether abdominal obesity (e.g., high waist circumference) is associated with tooth loss among individuals without obesity.

A clinical study on the relationship between chronic rhinosinusitis and bronchial asthma.

Objective: To investigate the correlation between chronic rhinosinusitis (CRS) and bronchial asthma, focusing on the CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP), as well as their impact on lung function.

Methods: A total of 141 patients diagnosed with chronic nasal-sinus inflammation were included in this study. Clinical data, including medical histories, nasal endoscopy scores, CT scores, symptom scores, and quality of life assessments, were collected.

Aggregation-induced emission luminogens for intracellular bacteria imaging and elimination.

Intracellular bacterial infections are a serious threat to human health due to their ability to escape immunity and develop drug resistance. Recent attention has been devoted to identifying and ablating intracellular bacteria with fluorescence probes. Aggregation-induced emission luminogens (AIEgens) photosensitizers as fluorescence probes possess excellent photostability and rapid response, which have emerged as powerful fluorescent tools for intracellular bacterial detection and antibacterial therapy.

Up-regulation of myelin-associated glycoprotein is associated with the ameliorating effect of omega-3 polyunsaturated fatty acids on Alzheimer's disease progression in APP-PS1 transgenic mice.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive behavioral and cognitive impairments. Despite growing evidence of the neuroprotective action of omega-3 polyunsaturated fatty acids (PUFAs), the effects and mechanism of omega-3 PUFAs on AD control are yet to be clarified. By crossing male heterozygous fat-1 mice with female APP/PS1 mice, we assessed whether elevated tissue omega-3 PUFA levels could alleviate AD progression and their underlying mechanism among the offspring WT, APP/PS1 and APP/PS1 × fat-1 groups at various stages.

A controlled study: Evaluating the clinical impact of a nurse-centred multidisciplinary hospice care model on anxiety, depression, and quality of life in patients with advanced malignant tumours.

Objective: To explore the clinical effect of a nurse-centred multidisciplinary collaborative hospice care model in patients with advanced malignant tumours.

Methods: A total of 30 patients with advanced malignant tumours were hospitalised and randomly divided into a study group and a control group, each consisting of 15 cases. The study group received nurse-led multidisciplinary collaborative hospice care, whereas the control group underwent high-quality nursing intervention.