Antimicrobial Resistance of in Bloodstream Infections in Hospitalized Patients in Southern Poland.

The aim of this study was to highlight antimicrobial resistance among isolated from bloodstream infections in hospitals in southern Poland. The present study includes laboratory-confirmed secondary bloodstream infections (LC-BSIs), in the years 2015-2018, in hospitalized adult patients (≥18). Episodes of BSIs were defined according to the strictly described guidelines.

Serum concentration of interleukin 6 is related to inflammation and dyslipidemia in patients with psoriasis.

Introduction: Patients with psoriasis and psoriatic arthritis (PsA) have metabolic disturbances, which may be due to chronic inflammation.

Aim: Because interleukin-6 (IL-6) regulates both metabolic and inflammatory processes, we evaluated IL-6 as a potential marker of inflammation and metabolic disturbances in psoriasis.

Material And Methods: This study involved 93 patients with psoriasis, including 31 patients with concurrent PsA.

Serum lipid metabolism in psoriasis and psoriatic arthritis - an update.

Introduction: Psoriasis and psoriatic arthritis (PSA) are chronic, inflammatory, systemic diseases characterized by metabolic abnormalities, including an increased cardiovascular risk and an oxidative imbalance. This study assessed blood parameters of lipid metabolism and markers of oxidative stress in patients with psoriasis and PSA.

Material And Methods: The study included 93 patients with psoriasis (31 patients with PSA and psoriasis, 62 patients with psoriasis vulgaris), and 60 healthy, age-matched controls.

Clavicle fracture associated with atlantoaxial rotatory displacement, type II in an 8-year-old girl: A case report.

Rationale: Fracture of the clavicle is a very common injury in children. However, association between clavicle fracture and atlantoaxial rotatory displacement is rarely observed.

Patient Concerns: We present a case of an 8-year-old girl, who suffered a right clavicle fracture as a result of a sledge accident.

Novel Mutation of the Gene in Patients with Cleidocranial Dysplasia.

Cleidocranial dysplasia (CCD) is an autosomal dominant disorder linked to mutations in the Runt-related transcription factor 2, encoded by the gene, which is essential for osteoblast differentiation and skeletal development. Here, we describe a novel nonsense mutation (c.532C>T; p.

Bilateral congenital torticollis: a case report with 25 years of follow-up.

Unilateral congenital sternocleidomastoid muscle (SCM) contracture causing torticollis is well known. Although the unilateral muscular torticollis is quite often recognized, a bilateral contracture of SCM muscle is very rare. A review of the literature showed only three cases of bilateral congenital torticollis reported over the last two decades.

Cleidocranial dysplasia and RUNX2-clinical phenotype-genotype correlation.

Runt-related transcription factor 2 (RUNX2/Cbfa1) is the main regulatory gene controlling skeletal development and morphogenesis in vertebrates. It is located on chromosome 6p21 and has two functional isoforms (type I and type II) under control of two alternate promoters (P1 and P2). Mutations within RUNX2 are linked to Cleidocranial dysplasia syndrome (CCD) in humans.

Shape of growth plate of proximal femur in children and its significance in the aetiology of slipped capital femoral epiphysis.

Purpose: The main objective of the study was to present the influence of the morphological shape of the proximal femoral growth plate in children as one of the risk factors for the incidence of slipped capital femoral epiphysis (SCFE) in adolescents.

Methods: This research is based on the X-ray, computed tomography (CT) and magnetic resonance imaging (MRI) data obtained for 100 children three to 13 years old, all treated at the Children's Orthopaedic Clinic and Rehabilitation Department and Department of Radiology Medical University of Lublin between 2005 and 2009. We took into account 83 children with healthy hip joints and 17 children with SCFE.

IFAP syndrome with severe cutaneous, neurologic and skeletal manifestations due to a novel MBTPS2 mutation in a Polish patient.

Background: Ichthyosis Follicularis, Atrichia and Photophobia (IFAP) syndrome is a rare genodermatosis due to mutations of the MBTPS2 gene. To date fewer than 40 cases have been described in the literature.

Objectives: To present the first case of IFAP diagnosed in Poland due to a novel mutation of MBTPS2, and to review the relevant literature on this rare genodermatosis.

Florid-reactive periostitis of the phalanges: a 2-case report.

Florid-reactive periostitis, also known as fibroosseous pseudotumor, is a benign bone lesion. It occurs rarely among pediatric patients. Usually, it affects the phalanges of the hands and feet, where most lesions concern the proximal phalanx.

Radiological picture of "unaffected" proximal femoral growth plate in children with unilateral Perthes disease.

Background. A changed radiological picture has Bern observed in the initial x-rays of the unaffected proximal femoral growth plate in children with unilateral Perthes disease. The present study seeks to determine whether a thicker, horizontal growth plate in an etiological factor in Perthes disease.

Remarks on the etiology and pathogenesis of Perthes' disease: an experiment-based hypothesis.

The literature on Perthes' disease points up the significance of specific anatomical conditions affecting vascularization of the femoral head, as well as immaturity and mechanical weakening of the bone tissue in the etiology and pathogenesis of this disorder in children. An experimental study using calf femurs as models confirmed the author's hypothesis that the areas most susceptible to mechanical stress are found in the immature subchondrial layer of the head and neck of the femoral bone. Further investigation of the results suggested that disturbances in the activity of the two growth zones (the epiphyseal growth cartilage and the growth plate) of the proximal femur contribute significantly to the etiology of Perthes' disease.

In-vitro mechanical impacts on calves' proximal femurs: significance of mechanical weakening of the femoral head in the etiology of Perthes disease in children.

Experimental research was conducted to determine the effects of mechanical forces on the hip joint in the etiology of Perthes disease in children. The authors aimed to identify areas of lower resistance to mechanical forces in a growing femoral head. Calves' femurs, used as experimental models, were repeatedly subjected to mechanical impacts.

[Femur head necrosis in haemophilia and after prolonged steroid therapy--description of two cases].

Clinical and radiological course of femoral head necrosis of known aetiology (in a boy, aged 8, with haemophilia and in a girl, aged 13, after prolonged steroid therapy) was compared with the typical course in children with Perthes disease.

[Congenital disorders of hemostasis in children with Perthes disease].

The level of selected parameters of the coagulation system and fibrynolysis (prothrombin time, partial thromboplastin time, fibrinogen level, albumin C system, V Leiden factor and III antithrombin level) in 25 children who had been treated with Perthes disease was evaluated. In three children prolonged prothrombin time occurred; in one child anomalous protein C system was noted. The remaining parameters were normal in all children.

Capital femoral epiphysis and growth plate of the asymptomatic hip joint in unilateral Perthes disease.

Radiograms of 173 children with unilateral Perthes disease were reviewed with particular reference to the presence of flattening and irregularity of the 'unaffected' epiphyses. The slope and shape of the growth plate were also evaluated. About 35% of children with Perthes disease showed changes of the unaffected proximal femur in the first radiograms of the hip joints.

[Radiologic and clinical evaluation of the wrist in some movement disorders of children].

The wrist angle in X-ray pictures of the hand in 47 children, aged 6-16 years, treated for bone growth disorders, was evaluated. The obtained results were compared with the wrist angle in normal children. The increase of the wrist angle was observed in deformations: dwarfism, gargoylism and dysplasia multiplex, and the decrease of this angle in the Turner syndrome.

Double-elevating osteotomy of tibiae in the treatment of severe cases of Blount's disease.

The results of operative correction of 13 cases of tibia vara in 10 children with advanced infantile Blount's disease are presented. All of the children were operated by "double-elevating" osteotomy. An essential element of this procedure was the reconstruction of the horizontal level of the medial tibial plateau.

Ischemia of the femoral head in Perthes' disease: is the cause intra- or extravascular?

We examined selected parameters of the clotting and fibrinolytic system of 26 boys with aseptic necrosis of the femoral head and then evaluated the pressure of the fluid in the cavity of the hip joint with the help of ultrasonic examination. No disturbances were discovered in the coagulation system and ultrasonography ruled out the possibility that extravascular pressure had caused the necrosis. We confirmed a significantly greater level of alpha 1-antitrypsin in comparison with the control group, which may indicate a decrease in fibrinolytic activity and confirm the hypothesis that there is an intravascular pre-disposition towards the appearance of clots in the vascular system of the femoral head in patients with Perthes' disease.

Intraarticular bleeding in children with hemophilia: the prevention of arthropathy.

The treatment of about 400 hemorrhages in the joints of 46 children with hemophilia A are described. The procedures varied according to the location and seriousness of the bleeding and the level of the clotting factor. We always transfused just enough cryoprecipitate to obtain a hemostatic level of factor VIII.

[Calcinosis tumoralis. Pharmacological alternatives to surgical treatment and its etiological justification].

A detailed case history of a 6 years old child, including biochemical and radiological examinations, has been presented. The disease started with a commonplace contusion of the patella and rapidly progressed after arthrotomy. Dihydroxy-aluminium-natrium carbonicum was applied as well as the low calcium and phosphorus diet.