Introduction Intestinal carriage of multidrug-resistant organisms (MDROs) in healthy populations could amplify resistant bacteria, which may increase the risk of infections by these bacteria in the community and in the hospital. This study investigated the prevalence of colonization of multidrug-resistant (MDR) bacteria in the intestines of healthy individuals in South India. Methods A prospective study was conducted for six months at a tertiary care teaching hospital.
View Article and Find Full Text PDFIntroduction India is currently experiencing a colossal increase in the number of medical colleges and a concurrent rise in the number of medical students pursuing Bachelor of Medicine and Bachelor of Surgery (MBBS). Shortages in the teaching faculty and infrastructural and logistic limitations like the availability of patients and clinical material are severely affecting the quality of medical education. Moreover, privatization has been instrumental in transforming medical education into a lucrative business compromising its quality.
View Article and Find Full Text PDFspecies (spp.) are gram-positive cocci that are rarely reported in humans. These bacteria share physiological, cultural, and biochemical properties with spp.
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October 2024
Introduction (PA) is a bacterial species commonly isolated from human clinical specimens. Despite being present in the environment as a saprophyte, PA possesses the ability to cause human infections, especially among debilitated patients. It is therefore essential to understand the genomic imprints of antimicrobial resistance (AMR) and virulence genes associated with PA isolated from patient samples.
View Article and Find Full Text PDFRecent reports of fatal meningoencephalitis from Kerala, South India, are creating ripples among medical and health administrations. Free-living amoebae (FLA) have been attributed to these infections. Despite their free-living nature, these amoebae have been recognized as potential opportunistic organisms that occasionally cause infections in immunocompetent and immunocompromised individuals.
View Article and Find Full Text PDFVector-borne microbial diseases are ubiquitous, and their management remains elusive. Such diseases with zoonotic potential result in public health challenges requiring additional control and preventive measures. Despite their cosmopolitan presence, vector-borne infections are neglected due to their endemicity in specified geographical regions.
View Article and Find Full Text PDFCurrently, there is unavailability of disease-modifying medication for Alzheimer's disease (AD), a debilitating neurological disorder. The pathogenesis of AD appears to be complex and could be influenced by the glymphatic system present in the central nervous system (CNS). Amyloid-beta (Aβ) and other metabolic wastes are eliminated from the brain interstitium by the glymphatic system, which encompasses perivascular channels and astroglial cells.
View Article and Find Full Text PDFIntroduction Menopause is an important milestone in the lives of women. Despite it being a natural phenomenon, menopause brings a lot of changes in a woman's life, which significantly affects their health and well-being. Menopause involves the cessation of hormone production necessary for menstrual cycles and fertility of females.
View Article and Find Full Text PDFIntroduction Efficient delivery of medical education (ME) is crucial to improving the standards of future physicians or clinicians. India has been experiencing an enormous increase in medical colleges and student admissions into medicine. This has resulted in overcrowding and compromised the student-to-teacher ratio.
View Article and Find Full Text PDFBackground And Aim: Dengue and SARS-CoV-2 coinfection is commonly encountered and constantly reported in particularly the dengue-endemic regions thus posing a co-epidemic threat. Coinfection is also significantly associated with morbidity and mortality. Comorbidity risk during a coinfection is of a greater concern.
View Article and Find Full Text PDFIntroduction Antimicrobial resistance (AMR) has become a menace, spreading among bacterial species globally. AMR is now recognized as a silent pandemic responsible for treatment failures. Therefore, an effective surveillance mechanism is warranted to understand the bacterial species isolated from human clinical specimens.
View Article and Find Full Text PDFAs the mankind counters the ongoing COVID-19 pandemic by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), it simultaneously witnesses the emergence of mpox virus (MPXV) that signals at global spread and could potentially lead to another pandemic. Although MPXV has existed for more than 50 years now with most of the human cases being reported from the endemic West and Central African regions, the disease is recently being reported in non-endemic regions too that affect more than 50 countries. Controlling the spread of MPXV is important due to its potential danger of a global spread, causing severe morbidity and mortality.
View Article and Find Full Text PDFAllergy and immunological disorders like autoimmune diseases are vastly prevalent worldwide. These conditions account for a substantial amount of personal and social burden. Such illnesses have lengthy, uncertain, and spotted courses with unpredictable exacerbations.
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March 2024
Introduction An enormous increase in antimicrobial resistance (AMR) among bacteria isolated from human clinical specimens contributed to treatment failures. Increased surveillance through next-generation sequencing (NGS) or whole genome sequencing (WGS) could facilitate the study of the epidemiology of drug-resistant bacterial strains, resistance genes, and other virulence determinants they are potentially carrying. Methods This study included 30 (.
View Article and Find Full Text PDFNeglected tropical diseases (NTDs) are a group of diseases caused by diverse organisms, affecting millions of people in tropical and subtropical conditions. NTDs are more prevalent among people who live in poverty, without access to clean water, adequate sanitation, and quality health care. Most NTDs are chronic conditions and are potentially disablers than killers, leaving behind a trail of social consequences.
View Article and Find Full Text PDFCancer is a complex disease that can affect different parts of the body. The rates of cancer have shown an increasing trend in the past decade. A majority of cancers are detected late, therefore becoming untreatable and resulting in significant mortality.
View Article and Find Full Text PDFRecurring outbreaks in the United States is a growing public healthcare concern. Although no associated reported death, 17 were hospitalized out of the 18 reported illnesses in the recent outbreak in 15 US states. The United States has experienced about 30 outbreaks in the last decade with 524 Listeriosis cases and 80 deaths.
View Article and Find Full Text PDFBackground And Aim: Severe morbidity and mortality due to seasonal infectious diseases are common global public health issues. Vector-borne viral illnesses like dengue and chikungunya overload the healthcare systems leading to critical financial burden to manage them. There is no effective drug or vaccine currently available to control these two diseases.
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