Publications by authors named "Kandavalli Manipriya"
Role of high-fat diet on letrozole-induced polycystic ovarian syndrome in rats.
Eur J Pharmacol
February 2022
Article Synopsis
- Polycystic ovary syndrome (PCOS) is a common hormonal disorder affecting women of reproductive age, and the study aimed to create a better animal model for PCOS by combining letrozole (LET) treatment with a high-fat diet (HFD).
- The results showed that both the LET and LET + HFD groups developed ovarian cysts and had hormonal imbalances, with higher testosterone but lower estradiol and progesterone levels.
- The LET + HFD group exhibited significant metabolic changes, such as increased body weight and altered blood markers, suggesting it is a more accurate representation of the metabolic issues seen in human PCOS compared to the LET-only model, which lacked these metabolic anomalies.