Green-synthesized CuO and ZnO nanoparticles derived from Calotropis gigantea (Apple of Sodom): enhancing plant growth, efficient dye removal, and potent antibacterial applications.

Nanoparticles, owing to their unique physicochemical properties, have garnered significant attention in various scientific disciplines, including materials science, chemistry, biology, and environmental engineering. In recent years, the synthesis of metal oxide nanoparticles, such as NiO, FeO, ZnO, SnO, and CuO via green routes, has gained attraction due to their diverse applications in fields ranging from catalysis and electronics to medicine and environmental remediation. This study focuses on the green synthesis of copper oxide (CuO) and zinc oxide (ZnO) nanoparticles using Calotropis gigantea (Apple of Sodom) leaf extract as a reducing agent and stabilizer, with zinc nitrate (ZnNO.

Accuracy of Beamscan Software in Determining the Inflection Point from the FFF Beam Profile Using Several Array Detectors.

Objective: The goal of this study is to determine the accuracy of the PTW Beamscan program in determining the inflection point from Flattening Filter Free Beam Profile utilizing Multiple Detectors.

Methods: True Beam Linear Accelerator with 6FFF and 10FFF Photon Energies and 10 cm, 15 cm and 20 cm Field Sizes were used for this study. Profile measurements were taken with PTW's 729, 1,500, and 1,600 and the Starcheck system, the Pinpoint 3D with Beamscan system, and Linac's EPID.

Dosimetric Evaluation of Semiflex Three-dimensional Chamber under Unflatten Beam in Comparison among Different Detectors.

Purpose: The goal of this study is to investigate the dosimetric properties of a Semiflex three-dimensional (3D) chamber in an unflatten beam and compare its data from a small to a large field flattening filter-free (FFF) beam with different radiation detectors.

Methods: The sensitivity, linearity, reproducibility, dose rate dependency, and energy dependence of a Semiflex 3D detector in flattening filter and filter-free beam were fully investigated. The minimum radiation observed field widths for all detectors were calculated using lateral electronic charged particle equilibrium to investigate dosimetric characteristics such as percentage depth doses (PDDs), profiles, and output factors (OPFs) for Semiflex 3D detector under 6FFF Beam.

Facile engineering of aptamer-coupled silk fibroin encapsulated myogenic gold nanocomposites: investigation of antiproliferative activity and apoptosis induction.

Nanocomposites selectively induce cancer cell death, holding potential for precise liver cancer treatment breakthroughs. This study assessed the cytotoxicity of gold nanocomposites (Au NCs) enclosed within silk fibroin (SF), aptamer (Ap), and the myogenic Talaromyces purpureogenus (TP) against a human liver cancer cell (HepG2). The ultimate product, Ap-SF-TP@Au NCs, results from a three-step process.

Unraveling the Therapeutic Potential of Muscle Strengthening Exercises for Reversing Diabetes Mellitus.

Background: Millions of people worldwide are affected by the serious consequences of diabetes mellitus, which is a major global health concern. We analyze the possibility of muscle- strengthening activities as an appropriate therapeutic strategy for controlling the progression of diabetes mellitus in this comprehensive review. In this review, we explore the molecular processes underlying the glucose uptake in skeletal muscle, revealing how exercise can improve insulin sensitivity and glucose homeostasis.

Sinus of Valsalva Aneurysm: A Potential Case of Filamin A Mutation.

Filamin A is a protein essential for cytoskeleton production, encoded by the X-lined dominantly inherited FLNA gene. A deficiency in filamin A can lead to cardiac valvular dysplasia and periventricular nodular heterotopia in the brain. Notably, periventricular heterotopia Type 1 has associations with cardiovascular abnormalities.

A Cross-Sectional Study to Find the Correlation between the Level of Fluoride in Drinking Water, Dental Fluorosis and Associated Risk Factors- A Original Research.

Background: The present study was conducted to assess the relationship between drinking water fluoride (F) levels, dental fluorosis dental caries, and associated risk factors in the elderly population.

Materials And Methods: A cross-sectional analytical study was conducted on 50 patients aged 25-60 years, selected by stratified random sampling from different areas with different levels of naturally occurring F in drinking water. The patients were assessed for dental fluorosis according to WHO basic survey guidelines.

Maternal dendritic cells influence fetal allograft response following murine in-utero hematopoietic stem cell transplantation.

Background: Intrauterine hematopoietic stem cell transplantation (IUT), potentially curative in congenital haematological disease, is often inhibited by deleterious immune responses to donor cells resulting in subtherapeutic donor cell chimerism (DCC). Microchimerism of maternal immune cells (MMc) trafficked into transplanted recipients across the placenta may directly influence donor-specific alloresponsiveness, limiting DCC. We hypothesized that dendritic cells (DC) among trafficked MMc influence the development of tolerogenic or immunogenic responses towards donor cells, and investigated if maternal DC-depletion reduced recipient alloresponsiveness and enhanced DCC.

Non-Pathological Psychological Distress among Mainland Chinese in Canada and Its Sociodemographic Risk Factors amidst the Pandemic.

Unlabelled: The COVID-19 pandemic has exacerbated health inequalities, with a potentially heightened mental health risk for Mainland Chinese in Canada, given the rising anti-Chinese discrimination, and barriers in assessing health services. In this context, this study aimed to assess non-pathological psychological distress towards COVID-19 and identify its sociodemographic risk factors among Mainland Chinese in Canada at the early stages of the pandemic.

Methods: A sample of 731 Mainland Chinese aged 16 or older completed an on-line survey to examine their attitudes, behavioural, and psychological responses towards COVID-19.

Targeting caveolae to pump bispecific antibody to TGF-β into diseased lungs enables ultra-low dose therapeutic efficacy.

The long-sought-after "magic bullet" in systemic therapy remains unrealized for disease targets existing inside most tissues, theoretically because vascular endothelium impedes passive tissue entry and full target engagement. We engineered the first "dual precision" bispecific antibody with one arm pair to precisely bind to lung endothelium and drive active delivery and the other to precisely block TGF-β effector function inside lung tissue. Targeting caveolae for transendothelial pumping proved essential for delivering most of the injected intravenous dose precisely into lungs within one hour and for enhancing therapeutic potency by >1000-fold in a rat pneumonitis model.

Comparing the knowledge and awareness of cervical and breast cancer among medical and nonmedical students of a private institution in South India.

Context: Cervical and breast cancer is the most leading cause of death among women globally. Cervical and breast cancer can be cured if detected early.

Aims: The aim of the study was to compare the knowledge and awareness of cervical and breast cancer among medical and nonmedical students of a private institution in South India.

Perceived and Experienced Anti-Chinese Discrimination and Its Associated Psychological Impacts Among Chinese Canadians During the Wave 2 of the COVID-19 Pandemic.

The current study examined the sociodemographic factors associated with perceived and experienced anti-Chinese discrimination and discrimination as a predictor of psychological distress and loneliness among Chinese Canadians. A cross-sectional online survey was conducted in early 2021 with a sample of 899 Chinese Canadians (i.e.

Event Segmentation Enhances Older Adults' Reactive Cognitive Control Bias.

The present study examined the effect of event segmentation on cognitive control mode use in a sample of older adults ( = 30;  = 73,  = 4.75) using a modified AX-Continuous Performance Test (AX-CPT). This task included a perceptual event boundary between each cue and its forthcoming probe by means of a spatial shift across the left and right side of the display.

Influence of Padina gymnospora on Apoptotic Proteins of Oral Cancer Cells-a Proteome-Wide Analysis.

Oral carcinoma is one of the most vicious forms of cancer with a very low survival rate, as its patients often respond poorly to conventional chemotherapy. Presently several researchers are attempting to pursue an alternative to this therapy using natural products. Considering the promising strategy and induction of apoptosis to target the cancer cells, we evaluated the influence of a seaweed Padina gymnospora (15 µg/ml and 20 µg/ml) in enhancing apoptosis of oral cancer cells (KB-CHR-8-5) after 24-h incubation.

Development of a low-resource wearable continuous gesture-to-speech conversion system.

Purpose: Mild to profound hearing impairment places limits on effective communication and day-to-day interaction. Sign language, being the primary mode of communication for people with hearing loss, lacks communicative efficacy. A wearable assistive device that aims to convert sign language into speech is proposed to facilitate communication between the unimpaired population (untrained in sign language) and the hearing impaired population.

Cognitive Control in Young and Older Adults: Does Mood Matter?

The dual mechanisms of control framework (DMC) proposes two modes of cognitive control: proactive and reactive control. In anticipation of an interference event, young adults primarily use a more proactive control mode, whereas older adults tend to use a more reactive one during the event, due to age-related deficits in working memory. The current study aimed to examine the effects of mood induction on cognitive control mode in older (ages 65+) compared to young adults (ages 18-30) with a standard letter-cue (Experiment 1) and a modified face-cue AX-CPT (Experiment 2).

Rapid Detection of Pathogenic Bacteria by the Naked Eye.

O157:H7 and are common pathogens. Gram-negative bacteria, such as , contain high concentrations of endogenous peroxidases, whereas Gram-positive bacteria, such as , possess abundant endogenous catalases. Colorless 3,5,3',5'-tetramethyl benzidine (TMB) changes to blue oxidized TMB in the presence of and a low concentration of HO (e.

Functional magnetic nanoparticle-based affinity probe for MALDI mass spectrometric detection of ricin B.

The use of lactosylated FeO magnetic nanoparticles (MNP@LAC) has been explored as affinity probes against ricin B based on galactose-ricin B binding interactions. Lactose was bound onto the surface of aminated MNPs through the Maillard reaction. The enrichment of ricin B took ~1 h by incubating MNP@LAC with samples under shaking at room temperature, followed by magnetic isolation.

Magnetic Graphene Oxide-Based Affinity Surface-Assisted Laser Desorption/Ionization Mass Spectrometry for Screening of Aflatoxin B1 from Complex Samples.

Aflatoxin B1 (AFB1), commonly found in agriculture products, has been considered as a carcinogen. Thus, to develop analytical methods that can be used to rapidly screen the presence of AFB1 in complex samples is important. Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) uses inorganic materials as assisting materials to facilitate desorption/ionization of analytes.

Impact of COVID-19 on routine immunisation in South-East Asia and Western Pacific: Disruptions and solutions.

Background: Data on COVID-19-induced disruption to routine vaccinations in the South-East Asia and Western Pacific regions (SEAR/WPR) have been sparse. This study aimed to quantify the impact of COVID-19 on routine vaccinations by country, antigen, and sector (public or private), up to 1 June 2020, and to identify the reasons for disruption and possible solutions.

Methods: Sanofi Pasteur teams from 19 countries in SEAR/WPR completed a structured questionnaire reporting on COVID-19 disruptions for 13-19 routinely delivered antigens per country, based on sales data, government reports, and regular physician interactions.

Maternal microchimerism and cell-mediated immune-modulation enhance engraftment following semi-allogenic intrauterine transplantation.

Successful intrauterine hematopoietic cell transplantation (IUT) for congenital hemoglobinopathies is hampered by maternal alloresponsiveness. We investigate these interactions in semi-allogenic murine IUT. E14 fetuses (B6 females × BALB/c males) were each treated with 5E+6 maternal (B6) or paternal (BALB/c) bone marrow cells and serially monitored for chimerism (>1% engraftment), trafficked maternal immune cells, and immune responsiveness to donor cells.

and from marine macro-algae - isolation and characterization of agar-hydrolysing bacteria.

Macro-algae are a good source of agar oligosaccharides, which can be obtained through bacterial enzymatic hydrolysis. The agarase enzyme secreted by the micro-organisms cleaves the cell wall of the algae and releases agar oligosaccharides as degradation products with various applications. Agarolytic bacteria were isolated from the marine algae sp.

Comparative genomics of ocular Pseudomonas aeruginosa strains from keratitis patients with different clinical outcomes.

The several virulence and drug-resistance mechanisms of Pseudomonas aeruginosa responsible for poor clinical outcomes in keratitis patients remain largely unknown. Here, we investigated the distribution of virulence factors and drug resistance by genes, mutations, efflux-pump systems of P. aeruginosa strains from keratitis patients with different clinical outcomes, included of whole-genome sequenced and annotated our five P.

A Comparative Study Between Septal Quilting Sutures Without Nasal Packing and Only Nasal Packing Post-septal Correction.

Septal correction is the commonest surgery by rhinologists worldwide. We aimed at studying the comfort level of the patient with standard postoperative nasal packing with Merocel and placing quilting sutures in septum leaving the nose unpacked in the postoperative period. We conducted the study in the tertiary care centre enrolling 82 patients in a quasi-randomised method of odd and even numbers placing them in the nasal packing group and the quilting group respectively.