[Clinico-immunologic characteristics of mite-borne bronchial asthma].

The authors describe clinicoimmunological features of bronchial asthma caused by Dermatophagoides pteronyssinus. This type of asthma usually afflicts young persons, its course is mild. The main symptoms are dyspnea, rhinitis and conjunctivitis.

[Effect of mite allergens on the electrophoretic mobility of guinea pig lymphocytes].

The use of the method of electrophoretic mobility measurement has made it possible to demonstrate that Dermatophagoides pteronyssinus and Dermatophagoides farinae allergens are species-specific and possess common antigenic properties. The allergenic properties of D. pteronyssinus allergens are more pronounced than those of D.

[Allergenic activity of mites of the genus Dermatophagoides].

The allergenic activities of the laboratory batches of D. farinae allergens have been studied by the methods of indirect mast-cell degranulation, neuroglial cytocrit, electrophoretic mobility changes. D.

[Allergenic mites (Acariformes, Pyroglyphidae) in house dust].

Paper is the second part of the literature review on house dust mites (including 1985). It deals with the diagnosis of the dust mite allergy, the nature of the mite allergens, distribution and population density of the mites in various premises, seasonal population dynamics and population age structure of the dermatophagoid mites, life cycle and breeding of Dermatophagoides pteronyssinus and D. farinae on different food substrates.

[Effect of tomicide and the cell wall biopolymers of Streptococcus sp. Thom-1606 on mast cell degranulation].

The influence of tomicide and biopolymers obtained from the cell wall of Streptococcus sp. TOM-1606 on the degranulation of mast cells was studied. Among the biopolymers of the streptococcal cell-wall polysaccharide was shown to induce the highest destruction of mast cells (14.

[Comparative immunological characteristics of Daphnia allergens].

Materials on the study of Daphnia allergens are presented. Daphnia allergens have been shown to possess considerable sensitizing properties. The optimum method for the preparation of the allergen has been selected.

[Detection of mite antigens in house dust in Moscow].

The acarological+ study of dust samples from the homes of allergic patients and normal persons in Moscow mite antigens were detected, respectively, in 66.7% and 38.1% of homes.

[Mites in house dust and human allergoses].

The literary data on the study of the house-dust mites during the period from 1864 till 1983 are given. The methods of the house dust samples collection in flats and the methods of the house-dust mites isolation from the house dust are evaluated. The house-dust mites fauna including more than 130 species is described.

[Comparative iodination of a series of allergens].

The study of 27 allergens, carried out with the use of the standard technique of chloramine iodination by Hunter's method, revealed that the biological properties of the allergens were not essentially related to their capacity for binding 125I, this capacity being, on the whole, low. The blood sera of patients with allergic diseases were found to be no different from the blood sera of healthy persons in their capacity for binding 125I.

[Fractional composition of the allergens from cereals].

The composition of cereal allergens was studied and the specific activity of the fractions isolated from these allergens was determined. Four protein fractions were obtained from wheat flour by the method of salting out. None of the fractions thus obtained exceeded the whole wheat allergen in specific activity as determined in the indirect mast-cell degranulation (IMCD) test.

[Immunochemical and acarological study of mites].

The data derived in the study of Dermatophagoides pteronyssinus by microscopic and immunological assays (double radial immunodiffusion in 2 modifications and indirect rat mast cell degranulation) are provided. The immunochemical assays permitting the detection of mites in 93.3% of cases have been shown to compare very favourably with the microscopic techniques that make it possible to detect mites only in 41.

[Comparative evaluation of the specific activity of different types of allergens from Dermatophagoides pteronyssinus mites].

The specific activity of different kinds of allergens prepared from dermatophagoid mites has been studied by the method of the indirect mast cell degranulation and the method of changing the volume of cerebral glial cells in patients with the atopic form of bronchial asthma. In cases of sensitization to mites the presence of reagin and precipitin antibodies has been revealed. Allergens prepared from the mite medium and directly from mites have been found to possess almost the same specific activity.

[Role of the protein fraction of Bordetella pertussis in inducing experimental allergic encephalomyelitis].

B. pertussis protein fraction obtained by precipitation with trichloroacetic acid (TCA) stimulated the development of clinically and histologically pronounced experimental allergic encephalomyelitis (EAE) in guinea pigs when introduced together with a heterologous cerebral antigen, the two compounds forming an encephalitogenic mixture. The adjuvant activity of the TCA-precipitated fraction depended on its dose.

[Experimental allergic encephalomyelitis in guinea pigs caused by meningococci].

The sensitization of guinea-pigs with the mixture of meningococci and heterologous-cerebral tissue commonly induces the development of the typical clinical and pathomorphological picture of allergic encephalomyelitis. Unlike Mycobacterium tuberculosis and other acid-resistant bacterial and much like Bordetella pertussis, meningococci are capable of inducing allergic encephalomyelitis when introduced in mixture with oil without cerebral tissue. The vaccinal strain induces allergic encephalomyelitis with a more moderate course of the disease.

[Glial migration inhibition test in multiple sclerosis patients and its changes during treatment with immunosuppressants].

Results of examining the blood serum of 90 patients with disseminated sclerosis, 94 patients with other nervous diseases, and 20 healthy subjects using the glia migration inhibition test are presented. It is shown that the index of the glia migration inhibition (IGMI) gets higher during exacerbation of the disseminated sclerosis and drops in cases of relative stabilization of the clinical manifestations and remission. In the course of treatment with immunodepressants, such as, prednisolone (alone, or in combination with cyclophosphan) and antilymphocytic immunoglobulin, the IGMI falls down.

[Significance of cytotoxic anti-brain antibodies in the blood in infantile cerebral palsy].

The results of examining the blood serum of 75 children aged up to 2 years suffering from infantile cerebral paralysis of various gravity, as well as the results of analogous examinations of 21 healthy children are presented. Use was made of the immunological tests of glia migration inhibition, and of complement fixation. It was shown that the results of both tests characterized the gravity of the disease.

[Characteristics of an allergen from Dermatophagoides pteronyssinus mites].

The laboratory cultivation of house dust mites (Dermatophagoides pteronyssinus) was shown to yield the maximum amount of the mites in 10--12 weeks. Hair accumulated in electric razors and house dust mixed with hair from electric razors should be considered the most promising medium for their cultivation. Scarification tests with D.

[Role of allergic responses of peripheral blood leukocytes in the pathogenesis of experimental allergic (pertussis) encephalomyelitis].

Stable leukocytosis and lymphocytosis were observed in the peripheral blood of guinea pigs from the 14th day after their sensitization with B. pertussis oil suspension. A shift to the left occurred in the leukocytic count.

[Reactivity of the neuroglia in guinea pigs sensitized with Mycobacteria tuberculosis].

The changes in the glial cell reactivity depended on the phase and severity of the pathological process in the experimental allergic encephalomyelitis induced in guinea pigs by injection of Mycobacteria tuberculosis in a mixture of arlacel and vaselin. These reactivity changes measured by the method of inhibition of the glial cell migration in the tissue culture was specific of the nervous tissue antigens. The same changes in the reactivity could be induced in the tissue culture of the glial cells from the intact animals by the addition of sera or the lymph node cells from the actively sensitized guinea pigs.