Repurposing of antiviral drugs for COVID-19 and impact of repurposed drugs on the nervous system.

The recent pandemic, Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has devastated humanity and is continuing to threaten us. Due to the high transmissibility of this pathogen, researchers are still trying to cope with the treatment and prevention of this disease. Few of them were successful in finding cure for COVID-19 by including repurposed drugs in the treatment.

Production, Purification of Exo-Polygalacturonase from Soil Isolate Paecilomyces variotii NFCCI 1769 and Its Application.

The aim of the present study was to produce exo-polygalacturonase from potent soil isolate by submerged fermentation and its application for fruit juice treatment. Pectinase producing strains were selectively isolated from pectin industry waste. A selected isolate C2 was found to produce significant amount of exo-polygalacturonase.

Prevalence of high blood pressure among young rural adults in relation to height in childhood and adult body mass index.

Objective: Evidence, mostly based on developed countries, indicates that disease risks may be associated with changes in growth processes rather than a one-point phenomenon. In view of the increasing prevalence of hypertension in India, there is a need to understand how patterns of growth during early childhood and adolescence influence blood pressure in adulthood, particularly among rural populations in India.

Methods: The risk of hypertension was examined in 378 rural men older than 20 years who were measured for anthropometry during early childhood, adolescence, and as young adults in a community-based cohort study.

A potential probiotic culture ST2 produces siderophore 2,3-dihydroxybenzoylserine under intestinal conditions.

The aim of this study was to characterise siderophores of a culture bearing better probiotic qualities of human origin. In this direction, bacterial strain ST2 was isolated from faecal sample of 6-month-old healthy infant, which showed close similarity with Escherichia coli based on 16S r-RNA gene sequence analysis and biochemical characteristics. It was tested for siderophore production under in vitro iron limiting intestinal conditions.

Bacillus spp. of human origin: a potential siderophoregenic probiotic bacteria.

Bacillus spp. ST13, isolated from human stool, was evaluated for siderophoregenic and probiotic qualities prior to its possible application for iron nutrition in humans and animals. It was tested for siderophore production in iron-limiting conditions and found to produce catecholate type of siderophore on the basis of high-performance liquid chromatography (HPLC), FT-IR, NMR, and mass spectra analysis.

Production of hyaluronic acid from Streptococcus zooepidemicus MTCC 3523 and its wound healing activity.

Exopolysaccharide produced and purified from Streptococcus zooepidemicus MTCC 3523 was identified as hyaluronic acid (HA) based on IR and NMR spectroscopy while its Mw was found to be 5.38 × 10(5)Da. HA produced passed bacterial endotoxin test and showed significant wound healing activity in Wistar rats on 12th and 16th day.