Publications by authors named "Kanchan Karmakar"
In root-nodule symbiosis, rhizobial invasion and nodule organogenesis is host controlled. In most legumes, rhizobia enter through infection threads and nodule primordium in the cortex is induced from a distance. But in dalbergoid legumes like Arachis hypogaea, rhizobia directly invade cortical cells through epidermal cracks to generate the primordia.
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- Research shows that low doses of ouabain, a cardiotonic steroid, promote growth in cardiac and vascular myocytes without significantly affecting sodium pumps.
- The study focuses on how a low dose of ouabain (10 nM) increases intracellular calcium levels and activates key enzymes like m-calpain and protein kinase C (PKC) in pulmonary artery smooth muscle cells, leading to cell proliferation.
- Findings suggest a signaling pathway involving increased calcium, m-calpain activation, and PKC that drives the transition of smooth muscle cells from one growth phase to another, indicating potential roles for ouabain in vascular health.
Protease inhibitors in potential drug development for Leishmaniasis.
Indian J Biochem Biophys
October 2013
Leishmaniasis is a deadly protozoan parasitic disease affecting millions of people worldwide. The treatment strategy of Leishmania infection depends exclusively on chemotherapy till date. But the treatment of the disease is greatly hampered due to high cost, toxicity of the available drugs and more importantly emergence of drug resistance.
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