Publications by authors named "Kanchan Chakma"

The presence of heavy metal contaminants in fish and shellfish in aquatic environments poses a risk to human health due to trophic transfer. This study determined the levels of various trace elements (Fe, As, Cr, Zn, Cu, Ni, Pb, and Cd) in the muscles, gills, and liver of hilsa (Tenualosa ilisha) and prawn (Macrobrachium rosenbergii) samples obtained from the Tetulia River, Bangladesh. The results showed that the level of trace elements in different body parts differed significantly (P < 0.

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Epigenetic gene silencing by aberrant DNA methylation is one of the important mechanisms leading to loss of key cellular pathways in tumorigenesis. Methyl-CpG-targeted transcriptional activation (MeTA) reactivates hypermethylation-mediated silenced genes in a different way from DNA-demethylating agents. Microarray coupled with MeTA (MeTA-array) identified seven commonly hypermethylation-mediated silenced genes in 12 pancreatic ductal adenocarcinoma (PDAC) cell lines.

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Article Synopsis
  • * LHX6 was found to be significantly downregulated in most pancreatic cancer cell lines due to increased promoter hypermethylation and histone deacetylation, and it was also methylated in over half of primary pancreatic cancer specimens.
  • * Reactivating LHX6 in pancreatic cancer cells reduced their growth, while silencing it increased proliferation in cells with higher LHX6 levels, indicating that LHX6 is crucial for regulating tumor-suppressive genes during pancreatic tumor development.
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We have analyzed haplotypes for 17 Y chromosomal STR loci in Bangladeshi mainstream Bengali population and four largest ethnic groups inhabiting the North-Eastern and Southern region of Bangladesh using AmpFlSTR® Yfiler® PCR amplification systems. A total of 667 haplotypes from Bangladeshi Bangali, 157 from Rakhine, 144 from Marma, 112 from Hajong, and 136 from Manipuri individuals were observed with corresponding discrimination capacity (DC) of 0.973 for Bengali, 0.

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