Publications by authors named "Kanayo Okwuasaba"
Article Synopsis
- Mononuclear cells are important in understanding HIV-associated neurocognitive disorders (HAND), especially in African populations, but research on this is limited.
- A study with 190 HIV-infected individuals in Nigeria measured various activation markers and assessed cognitive impairment using a neuropsychological test battery and daily living activities.
- Results showed higher levels of certain markers (sCD14 and MCP-1) in patients with neurocognitive impairments, indicating a correlation between monocyte activation and the severity of HAND, warranting further investigation into underlying mechanisms and gender differences.
The potential role of gender in the occurrence of HIV-related neurocognitive impairment (NCI) and associations with markers of HIV-related immune activity has not been previously examined. In this study 149 antiretroviral-naïve seropositive subjects in Nigeria (SP, 92 women and 57 men) and 58 seronegative (SN, 38 women and 20 men) were administered neuropsychological testing that assessed 7 ability domains. From the neuropsychological test scores was calculated a global deficit score (GDS), a measure of overall NCI.
View Article and Find Full Text PDFDetailed neuropsychological testing was performed on 133 human immunodeficiency virus (HIV) seropositive (SP) and 77 HIV seronegative (SN) individuals, 86 % with early stage HIV infection in Nigeria, to determine the frequency of HIV-related neurocognitive impairment among the HIV-infected group. The tests were administered to assess the following seven ability domains: speed of information processing, attention/working memory, executive functioning, learning, memory, verbal fluency, and motor function motor. Demographically corrected individual test scores and scores for each domain or reflecting a global deficit (a global deficit score, or GDS) were compared for the SP and SN groups.
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