[INFLAMMATION AND CARDIAC INSUFFICIENCY ASSOCIATED WITH INFECTIOUS ENDOCARDITIS].

The study included 62 patients with uncomplicated primary and secondary infectious endocarditis admitted to S.PBotkin city hospital from 2011 to 2014. The emphasis is laid on diagnostic significance of dynamic measurements of the levels of C-reactive protein, tumour necrosis factor and highly sensitive troponin-1 for the evaluation of activity of the infectious/toxic process, severity of the disease, and detection of complications.

[Combined endoscopic diagnostics with catheter confocal endomicroscopy for gastric neoplasia detection].

The analysis of combined endoscopic diagnostics with catheter confocal laser endomicroscopy (CCLE) for detection of gastric neoplasia in 103 patients is presented in the article. It was described the main principles of catheter confocal laser endomicroscopy by using of Cellvizio-system ("Mauna Kea Technologies", France). All patients underwent esophagogastroduodenoscopy before catheter confocal laser endomicroscopy.

[Injuries to myocardium in infectious endocarditis].

Clinical and morphological characteristics of myocardium in infectious endocarditis (IE) are described as exemplified by pathological changes in the vascular bed, stroma, and myofibrils. Multiple sclerotic changes in myocardium in the form of "sheath sclerosis" were revealed. It is shown that progress of cardiac insufficiency in IE may be due to specific changes in the heart muscle.

[Clinical and morphological aspects of infectious endocarditis].

Comparative analysis of anamnestic, clinical, laboratory and instrumental data involved 106 patients with infectious endocarditis treated in S.P. Botkin City Clinical Hospital in 2000-2011 and 92 ones admitted in 1985-1977.

[Arteriovenous malformation as a source of recurrent gastrointestinal hemorrhages].

The paper describes a case of arteriovenous malformation (AVM) in a 64-year-old patient with recurrent gastric hemorrhage and posthemorrhagic iron-deficiency anemia. The source of hemorrhage was detected by esophagogastroduodenoscopy. AMV should be treated surgically, by excising the portion of antral mucosal portion of the stomach (mucosectomy).

[Morpho-immunological criteria for diagnosis of gastritis associated with Helicobacter pylori].

31 bioptates in the antral mucosa of 24 patients with a chronic gastritis and a body of a stomach for revealing H. pylori were being analysed and for the further studying morpho-immunology communications. The presence of H.

[Description of a clinical case of recurrent gastrointestinal bleeding, were caused by arteriovenous malformation of the stomach].

We described a clinical case of recurrent gastrointestinal bleeding caused by arteriovenous malformation of the stomach.

[The stomach and duodenum condition in patients with chronic obstructive lung diseases].

Examining the gastroduodenal mucosa (GDM) in 61 patients with chronic obstructive pulmonary diseases (COPD) showed changes in the areas studied in all cases. GDM atrophy increased with the severity of COPD. Helicobacter pylori are essential in developing gastric pathology in patients with mild bronchopulmonary disease.

[Profuse gastric bleeding in a female with Dieulafois syndrome].

Dieulafois syndrome is a rare congenital pathology with profuse gastric bleeding due to the damage to arterial wall in the submucosa layer. The case illustrates difficulties encountered in the treatment of such patients.

[Computer program for the analysis of clinical diagnostic errors based on a pathology database].

The program is tested on the material of 882 autopsy protocols. All parts of clinical and pathology diagnoses were included into the generation of the data base. Automatized analysis allowed to assess main characteristics of the patient material with a histogram demonstration of group statistics according to all positions considered as well as to obtain information on the influence of more complex pathology diagnosis of a main disease, sex and age on the frequency of clinical diagnosis mistakes.

[Reflux gastritis in duodenal ulcer].

The results of a comprehensive examination of 44 patients with duodenal ulcer are analyzed. Reflux gastritis was detected in almost 50% of the patients. X-ray method, gastroduodenoscopy, and radiologic method for measuring the duodenal reflux in gastric contents portions were employed to diagnose duodenogastric reflux and reflux gastritis.

[The functional morphology of the gastric mucosa in duodenal ulcer and in the late period after isolated selective proximal vagotomy].

Pretrophic and moderately atrophic gastritis is found in the antrum in patients with noncomplicated duodenal ulcer. Normal mucosa or superficial gastritis were observed in the gastric body. Statistically significant worsening of the gastritis of both stomach areas without pronounced atrophic forms, stable decrease of the acid production and the number of parietal cells with a mild increase of the gastrin-producing cells of the antrum are found 1 to 8 years after the selective proximal vagotomy.

[An analysis of the quality of the clinical diagnosis based on autopsy data].

The findings from 4359 autopsies made in 4 Moscow hospitals during 1986 were analyzed with two proposed tables. The primary materials were processes with a computer. Table 1 includes data on the total number of unrecognized cases by the main disease, major complications, concomitant and underlying diseases in terms of their category and cause of diagnosis discrepancy.

[Duodenogastric reflux and the pathomorphological picture of the stomach of patients operated on for duodenal ulcer].

The incidence and degree of gastroduodenal reflux and of pathomorphological alterations in the gastric mucosa were studied in 135 patients within the period from 3 to 25 years after the surgical treatment of ulcer disease of the duodenum.

[Clinico-morphologic characteristics of reflux gastritis in patients with peptic ulcer before and after surgical intervention].

Experimental and clinical studies convincingly indicate that duodenal-gastric reflux may provoke the development of reflux gastritis with a characteristic clinico-morphological complex. However, the clinical picture of reflux gastritis in patients with stomach ulcer is not always typical, is frequently masked by the underlying disease and therefore is difficult for diagnosis. The necessity of the use of the laboratory and instrumental methods arises, with an obligatory histological examination.

[Functional state of the gastrin-producing cells in duodenal ulcer patients].

Electron microscopic and specific immunofluorescent studies revealed enhanced hormonal activity of the antral part of the stomach manifested in hyperplasia of gastrin-producing cells in patients with duodenal ulcer. A relationship between the level of stimulated gastric secretion, number of gastrin-producing cells and their functional activity was established. No correlation was found between the values of acidity and levels of basal and stimulated gastrin or the dependence of the latter parameters on the number and functional activity of gastrin-producing cells.

[Cortisol and adipocyte indicators in exogenous-constitutional obesity].

The authors examined 64 patients with exogenous-constitutional adiposity, aged from 17 to 61 years (27 men and 37 women). The indices of the cortisol content were compared, depending on the patients' age, the degree of adiposity, heredity, and duration of the disease; the dependence and the correlation between cortisol and adipocyte morphology were ascertained. The blood cortisol content proved to depend on the patient's age and the degree of adiposity.

[Study of some oxidoreductases in nerve tissue culture].

A change in the activity of succinic dehydrogenase, of the NAD- and NADP-diaphorases was studied in the dissociated culture of the cerebellum of neonatal rats under the effect of immune serum of the animals with an experimental allergic pertussis encephalomyelitis. There was revealed an increase in the activity of oligodendrocytes following a 3-hour exposure with the immune serum and a reduction of the activity of the enzymes under study in the same cells after a 12-hour exposure of the cultures with the serum. In difference from oligodendrocytes, the astrocytes displayed a high activity of all the enzymes under study after a 12-hour exposure.

[Comparative morphometric study of the fatty tissue of obese patients following diet therapy].

Results of morphometric studies of the subcutaneous fat tissue in patients with the metabolic-alimentary form of obesity of 3rd degree are discussed. A total of 27 biopsy specimens obtained from obese patients before and after the course of complex therapy with statistical treatment of the data on the electronic computer type M-222 were studied. A regular correlation between the volume of lipocytes and body weight was revealed: with an increase in excessive weight there were observed corresponding changes in the size of fat cells.