Publications by authors named "Kanaoka K"
Background: This study aimed to determine the status of in-hospital cardiac rehabilitation (CR) and hospital-associated disability (HAD) for patients with acute myocardial infarction (AMI) aged >80 years.
Methods And Results: This study involved the Japanese Registry of All Cardiac and Vascular Diseases and the Diagnosis Procedure Combination databases, and included patients who were hospitalized with AMI from April 2014 to March 2021. Patients were categorized by the daily amount of CR: NA, not applicable; Low, 20-30 min; Moderate, 30-40 min; and High, >40 min.
Background: Infective endocarditis (IE) is still a fatal disease, and given its rarity, ongoing updates to patient characteristics and outcomes of IE are essential for providing precision diagnoses and effective treatments. This study sought to examine temporal trends in the clinical characteristics and in-hospital occurrence of adverse outcomes of IE.
Methods And Results: Using the Japan nationwide administrative database, we identified patients with IE in Japan from 2016 to 2021.
Article Synopsis
- Hospital-associated disability (HAD) is a decline in the ability to perform daily activities during hospitalization, particularly affecting older adults. This study investigates how inpatient cardiac rehabilitation (CR) impacts the development of HAD in older patients undergoing transcatheter aortic valve implantation (TAVI).
- Out of nearly 20,000 patients studied, those who participated in CR had a significantly lower prevalence of HAD (8.8%) compared to non-participants (14.2%), suggesting CR is beneficial in preventing this decline.
- However, the positive effects were less pronounced in patients with low body mass index (BMI) or lower Barthel Index (BI) scores at admission, indicating some patients might not benefit as much from CR.
Cardiovascular diseases (CVD) have imposed a substantial burden on population health and society. In Japan, the National Plan for the Promotion of Measures Against Cerebrovascular and Cardiovascular Disease, grounded in national legislation, seeks to improve the quality of care and standardize treatment for cerebrovascular disease and CVD. The plan emphasizes the need to develop standardized systems for collecting and disseminating medical information, as well as promoting data-driven research.
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- Acute autoimmune pericarditis (AAP) is a rare condition with varied causes, and this study aimed to understand its diagnosis and outcomes compared to acute idiopathic pericarditis (AIP).
- Out of 20,469 patients analyzed, 170 had AAP with diagnoses including systemic lupus erythematosus and rheumatoid arthritis, while 1.8% of AAP patients died during hospitalization and 8.8% experienced cardiac tamponade.
- The research found that AAP patients had a higher risk of cardiac tamponade compared to AIP patients, but both groups had similar rates of rehospitalization, highlighting the diagnostic diversity in AAP.
Evidence of the effectiveness of β-blockers in heart failure (HF) and atrial fibrillation (AF) in a contemporary cohort is controversial. This study investigated the association between the use of β-blockers and prognosis in hospitalized HF patients with and without AF in Japan. Patients hospitalized with the first episode of acute HF were identified from the National Database of Health Insurance Claims and Specific Health Checkups of Japan between April 2014 and March 2021.
View Article and Find Full Text PDFBackground: Guideline-directed medical therapy has become an important component of heart failure (HF) therapy, with sacubitril/valsartan as one of the recommended drugs; however, the real-world prognostic implications of sacubitril/valsartan uptitration are unclear.
Methods And Results: Patients with HF newly initiated on sacubitril/valsartan were registered in a retrospective multicenter study (REVIEW-HF). In all, 995 patients were divided into 3 groups according to the maximum dose achieved: high dose, sacubitril/valsartan 400 mg; intermediate dose, sacubitril/valsartan 200-<400 mg; and low dose, sacubitril/valsartan <200 mg.
Article Synopsis
- A study was conducted using data from over 522,000 ischemic stroke (IS) patients in Japan to explore the link between body mass index (BMI) and stroke-related disability.
- The study found that 60.1% of patients experienced worsening disability during hospitalization, with overweight patients having the best odds of better outcomes at discharge.
- The analysis revealed a U-shaped relationship between BMI and disability, suggesting that there's an optimal BMI of around 24.7 kg/m² for minimizing stroke-related disability.
Background: Patients with heart failure exhibiting low systolic blood pressure (SBP) have a poor prognosis. Sacubitril/valsartan reduces cardiovascular events; however, its use in patients with low SBP has not been fully examined. Therefore, in this study, we aimed to investigate the association between baseline SBP and adverse events (AEs) in patients starting sacubitril/valsartan therapy using data from a real-world registry in Japan.
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- The Japanese Catheter Ablation (J-AB) registry, launched in August 2017, is a nationwide voluntary study led by the Japanese Heart Rhythm Society focused on collecting data about catheter ablation procedures.
- In January 2022, the registry's data collection system shifted from REDCap to the Fountayn system to improve data management.
- By the end of 2022, the registry compiled data from 90,042 procedures across 614 hospitals, highlighting the types of arrhythmias, outcomes, and complications, with participants averaging 66.7 years old and 65.9% being male.
Background: Approximately 20% of patients with pulmonary alveolar proteinosis (PAP) present with pulmonary fibrosis on high-resolution computed tomography (HRCT). Although transbronchial lung cryobiopsy (TBLC) has recently been used to diagnose fibrotic interstitial lung disease, no studies have investigated whether TBLC is useful for the histopathological detection of pulmonary fibrosis coexisting with PAP. Therefore, the present study aimed to investigate the utility of TBLC for evaluating pulmonary fibrosis in patients with PAP.
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- The study explores how regional factors affect participation in cardiac rehabilitation (CR) and includes a large cohort of 2.7 million inpatients in Japan from 2012 to 2021.
- It categorizes hospitals into No-CR, High-CR, and Low-CR based on participation rates, finding that High-CR hospitals tend to have smaller service areas, more physicians per population, higher temperatures, and fewer primary industry workers.
- Key regional characteristics influencing High-CR hospitals include a lower consumer price index and a tendency for a younger population, thus highlighting the importance of local economic and demographic factors in CR participation.
Background/aim: Pneumonitis during durvalumab consolidation therapy after chemoradiotherapy (CRT) is a major cause of treatment discontinuation. Although previous studies have revealed an association between antinuclear antibody (ANA) positivity and the safety and efficacy of immune checkpoint inhibitors in advanced non-small cell lung cancer (NSCLC), there are no reports on durvalumab consolidation therapy. This study investigated the safety and efficacy of durvalumab after CRT in ANA-positive patients.
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- A study examined the link between changes in estimated glomerular filtration rate (eGFR) and the risk of developing end-stage kidney disease (ESKD) in the general population using data from Japanese health check-ups.
- Researchers analyzed data from over 115,000 individuals who had their eGFR measured three times between 2013 and 2020, discovering that those with a higher coefficient of variation in eGFR (CVeGFR ≥ 8.5%) had a significantly increased risk of ESKD.
- The findings suggest that annual variations in eGFR can indicate a higher risk of ESKD, independent of other traditional risk factors, highlighting the importance of monitoring eGFR in health assessments
Article Synopsis
- - This study focused on the safety and effectiveness of catheter ablation for treating atrial fibrillation (AF) in elderly patients, analyzing data from 170,017 procedures over four years.
- - Despite an increase in procedures for patients aged 80 and older, the overall complications rate was 2.8%, with higher risks as age increased, especially for those 85 and older.
- - Recurrence rates of AF after ablation were consistent across different age groups, indicating that with proper patient selection, AF ablation is a viable treatment option for older adults.
Article Synopsis
- The study evaluates the use and effectiveness of wearable cardiovascular defibrillators (WCD) in Japan, using a nationwide claims database.
- It identifies that patients with previous cardiopulmonary arrest (CPA), ventricular arrhythmia, or cardiomyopathy are more likely to need permanent implantable cardioverter-defibrillators (ICDs).
- Interestingly, the study notes that female patients are less likely to require these permanent devices, highlighting important demographic factors in treatment.
Background: Cardioprotective drugs have not been previously shown to improve the prognosis in patients with fulminant myocarditis presentation (FMP). We aimed to investigate whether cardioprotective drugs, including angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB) and β-blocker, administered during hospitalization improved the prognosis in patients with FMP.
Methods And Results: This multicenter cohort study conducted in Japan included 755 patients with clinically diagnosed FMP.
Article Synopsis
- Left ventricular (LV) thrombus can lead to serious complications like embolic stroke, and this study investigates the risks between two types of cardiomyopathy: ischemic (ICM) and nonischemic (NICM).
- The analysis involved 1,037 patients from a larger database, revealing no significant difference in embolic events between ICM (5.8%) and NICM (7.6%), although different subtypes of NICM (like dilated cardiomyopathy) showed varying levels of risk.
- The study concluded that while both types have similar overall risk for embolic stroke, dilated cardiomyopathy is associated with a higher risk than ischemic cardiomyopathy, highlighting the need to tailor management strategies
Measurement of flow-mediated vasodilation (FMD) in the brachial artery by using ultrasound is a well-established technique for evaluating endothelial function. To make the measurement quicker and simpler than the measurements of conventional ultrasound FMD (uFMD), we have developed a new noninvasive method, plethysmographic FMD (pFMD), to assess vascular response to reactive hyperemia in the brachial artery. The aim of this study was to determine the accuracy of measurement of pFMD in comparison to that of measurement of conventional uFMD.
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